Sixmile Creek is a tributary of the Big Sioux River, located in Brookings County, South Dakota, United States.
Sixmile Creek runs about in length[1] and intersects the western region of Brookings,[2] where it terminates about 0.12 mi (200 m) north of the city. As of May 2024, the city of Brookings is studying flood mitigation for the Sixmile Creek corridor.