SIVA1 explained

Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene.^{[1] [2]} This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.^[3]

Interactions

SIVA1 has been shown to interact with CD27.

Siva (protein)

Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells. Recent research has demonstrated that Siva is a direct transcriptional target for the tumor-suppressors p53 and E2F1. ^[4]

See also

• Siva (protein)

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Henke A, Launhardt H, Klement K, etal . Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein siva . J. Virol. . 74 . 9 . 4284–90 . 2000 . 10756043 . 10.1128/JVI.74.9.4284-4290.2000 . 111945 .
• Cao C, Ren X, Kharbanda S, etal . The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress . J. Biol. Chem. . 276 . 15 . 11465–8 . 2001 . 11278261 . 10.1074/jbc.C100050200 . free . 3476318 .
• Henke A, Nestler M, Strunze S, etal . The apoptotic capability of coxsackievirus B3 is influenced by the efficient interaction between the capsid protein VP2 and the proapoptotic host protein Siva . Virology . 289 . 1 . 15–22 . 2001 . 11601913 . 10.1006/viro.2001.1082 . free .
• Held-Feindt J, Mentlein R . CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors . Int. J. Cancer . 98 . 3 . 352–6 . 2002 . 11920585 . 10.1002/ijc.10207 . 12298972 . free .
• Xue L, Chu F, Cheng Y, etal . Siva-1 binds to and inhibits BCL-X(L)-mediated protection against UV radiation-induced apoptosis . Proc. Natl. Acad. Sci. U.S.A. . 99 . 10 . 6925–30 . 2002 . 12011449 . 10.1073/pnas.102182299 . 124505 . 2002PNAS...99.6925X . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Spinicelli S, Nocentini G, Ronchetti S, etal . GITR interacts with the pro-apoptotic protein Siva and induces apoptosis . Cell Death Differ. . 9 . 12 . 1382–4 . 2003 . 12478477 . 10.1038/sj.cdd.4401140 . free .
• Chu F, Borthakur A, Sun X, etal . The Siva-1 putative amphipathic helical region (SAH) is sufficient to bind to BCL-XL and sensitize cells to UV radiation induced apoptosis . Apoptosis . 9 . 1 . 83–95 . 2004 . 14739602 . 10.1023/B:APPT.0000012125.01799.4c . 2781477 .
• Py B, Slomianny C, Auberger P, etal . Siva-1 and an alternative splice form lacking the death domain, Siva-2, similarly induce apoptosis in T lymphocytes via a caspase-dependent mitochondrial pathway . J. Immunol. . 172 . 7 . 4008–17 . 2004 . 15034012 . 10.4049/jimmunol.172.7.4008. free .
• Fortin A, MacLaurin JG, Arbour N, etal . The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1 . J. Biol. Chem. . 279 . 27 . 28706–14 . 2004 . 15105421 . 10.1074/jbc.M400376200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Chu F, Barkinge J, Hawkins S, etal . Expression of Siva-1 protein or its putative amphipathic helical region enhances cisplatin-induced apoptosis in breast cancer cells: effect of elevated levels of BCL-2 . Cancer Res. . 65 . 12 . 5301–9 . 2005 . 15958577 . 10.1158/0008-5472.CAN-04-3270 . free .
• Gudi R, Barkinge J, Hawkins S, etal . Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD) . Oncogene . 25 . 24 . 3458–62 . 2006 . 16491128 . 10.1038/sj.onc.1209381 . free .
• Nestler M, Martin U, Hortschansky P, etal . The zinc containing pro-apoptotic protein siva interacts with the peroxisomal membrane protein pmp22 . Mol. Cell. Biochem. . 287 . 1–2 . 147–55 . 2006 . 16683188 . 10.1007/s11010-005-9082-6 . 20449471 .
• Severino A, Abbruzzese C, Manente L, etal . Human papillomavirus-16 E7 interacts with Siva-1 and modulates apoptosis in HaCaT human immortalized keratinocytes . J. Cell. Physiol. . 212 . 1 . 118–25 . 2007 . 17348035 . 10.1002/jcp.21011 . 23188116 .

Notes and References

1. Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF . CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein . Proc Natl Acad Sci U S A . 94 . 12 . 6346–51 . Jul 1997 . 9177220 . 21052 . 10.1073/pnas.94.12.6346 . 1997PNAS...94.6346P . free .
2. Web site: Entrez Gene: SIVA1 SIVA1, apoptosis-inducing factor.
3. Web site: Entrez Gene: SIVA1 SIVA1, apoptosis-inducing factor.
4. Fortin A, MacLaurin JG, Arbour N, etal . The proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1 . J. Biol. Chem. . 279 . 27 . 28706–14 . July 2004 . 15105421 . 10.1074/jbc.M400376200 . free .