Sisunatovir Explained

Cas Number:1903763-82-5
Pubchem:132016492
Unii:KE63TTO7WK
Kegg:D12200
Chembl:4297497
Synonyms:PF-07923568, RV521
Iupac Name:1'-5-(aminomethyl)-1-(4,4,4-trifluorobutyl)benzimidazol-2-ylmethyl]-6'-fluorospiro[cyclopropane-1,3'-indole]-2'-one
C:23
H:22
F:4
N:4
O:1
Smiles:C1CC12C3=C(C=C(C=C3)F)N(C2=O)CC4=NC5=C(N4CCCC(F)(F)F)C=CC(=C5)CN
Stdinchi:InChI=1S/C23H22F4N4O/c24-15-3-4-16-19(11-15)31(21(32)22(16)7-8-22)13-20-29-17-10-14(12-28)2-5-18(17)30(20)9-1-6-23(25,26)27/h2-5,10-11H,1,6-9,12-13,28H2
Stdinchikey:JOPCJJSYRPUEDS-UHFFFAOYSA-N

Sisunatovir is an investigational new drug that is being evaluated for the treatment of respiratory syncytial virus (RSV) infections.[1] It functions as an orally administered RSV fusion inhibitor, targeting the RSV-F protein on the viral surface to prevent viral replication.[2] Sisunatovir has been granted Fast Track designation by the U.S. Food and Drug Administration (FDA) due to its potential to address serious RSV infections, which can lead to severe respiratory conditions such as bronchiolitis and pneumonia.[3]

Notes and References

  1. Web site: Sisunatovir - ReViral . AdisInsight . Springer Nature Switzerland AG .
  2. Cockerill GS, Angell RM, Bedernjak A, Chuckowree I, Fraser I, Gascon-Simorte J, Gilman MS, Good JA, Harland R, Johnson SM, Ludes-Meyers JH, Littler E, Lumley J, Lunn G, Mathews N, McLellan JS, Paradowski M, Peeples ME, Scott C, Tait D, Taylor G, Thom M, Thomas E, Villalonga Barber C, Ward SE, Watterson D, Williams G, Young P, Powell K . Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion . Journal of Medicinal Chemistry . 64 . 7 . 3658–3676 . April 2021 . 33729773 . 10.1021/acs.jmedchem.0c01882 .
  3. Web site: Sisunatovir Fast-Tracked for Serious RSV Infection . Park B . 6 August 2020 . Medical Professionals Network . Haymarket Media, Inc. .