| Sir William Osler High School | |
| Motto: | Powerful, Passionate, Progressive |
| Location: | 1050 Huntingwood Drive |
| City: | Toronto |
| Province: | Ontario |
| Postalcode: | M1S 3H5 |
| Country: | Canada |
| Coordinates: | 43.7969°N -79.2859°W |
| Established: | 1974 |
| Type: | Public, High School Vocational High School |
| District: | Toronto District School Board |
| Grades: | 9-12 |
| Principal: | Mr.Ian Bain |
| Enrolment: | 201 (2018-2019) |
| Mascot: | Osler Eagles |
| Colors: | Blue and Yellow |
Sir William Osler High School (SWOHS), formerly Sir William Osler Vocational school is a small specialized public vocational high school in Toronto, Ontario, Canada. Located in the former suburb of Scarborough, it opened in 1975, and is named after Sir William Osler, a Canadian doctor and medical educator. Albert Campbell Collegiate Institute located northeast of Osler was initially named as Sir William Osler Collegiate Institute.