| Sipaliwini River | |
| Map: | Sipaliwini River 1930.jpg |
| Source1 Location: | 1.845°N -55.9875°W |
| Source1: | Tumuk Humak Mountains |
| Mouth Location: | 2.3439°N -56.8718°W |
| Mouth: | Courantyne River |
| Progression: | Courantyne River→Atlantic Ocean |
| Subdivision Type1: | Country |
| Subdivision Name1: | Suriname |
Sipaliwini River is a river of Suriname, the main source of the Courantyne River. It gives its name to the village of Sipaliwini Savanna and to the Sipaliwini District. It flows through the village of Kwamalasamutu. The name translates to thornback ray (sipari) river in the local Maroon dialect.