Pemphigus erythematosus explained

See also: List of target antigens in pemphigus.

Pemphigus erythematosus
Synonyms:	Senear–Usher syndrome

Pemphigus erythematosus is simply a localized form of pemphigus foliaceus with features of lupus erythematosus.^{[1] [2]}

Signs and symptoms

Pemphigus erythematosus patients typically present with superficially eroded lesions, or vesiculobullae, that may ooze and crust. This is especially common in areas of the body that are exposed to the sun, like the back, upper chest, and face.^[3]

The symptoms of pemphigus erythematosus usually appear slowly and progress slowly. The patient might not even be aware that their pemphigus erythematosus is photosensitive, even though the distribution of the lesions should indicate that they were induced by sunlight.^[3]

Causes

Pemphigus patients experience an autoimmune reaction that targets desmosomes.^[4] pemphigus erythematosus relapse has been linked to atorvastatin use.^[5] There has been one report of a new case of pemphigus erythematosus following topical ingenol mebutate treatment.^[6]

Diagnosis

Skin biopsies are used to diagnose pemphigus erythematosus. Immunofluorescence studies are performed on perilesional skin.^[3]

Treatment

It has been demonstrated that immunoadsorption and plasmapheresis are useful treatments for pemphigus erythematosus.^{[7] [8]}

See also

• Pemphigus
• List of cutaneous conditions
• List of conditions caused by problems with junctional proteins

Further reading

• Desai . Anand . Harris . Jessica . Motaparthi . Kiran . Enzyme-linked immunosorbent assay as a helpful diagnostic tool for pemphigus erythematosus with equivocal histologic and immunofluorescent findings . Dermatology Online Journal . 24 . 8 . 2018 . 1087-2108 . 10.5070/D3248041130 . 30677852 . none. free .
• Amerian . Mary L. . Ahmed . A. Razzaque . Pemphigus erythematosus . Journal of the American Academy of Dermatology . Elsevier BV . 10 . 2 . 1984 . 0190-9622 . 10.1016/s0190-9622(84)70025-9 . 215–222 . none.

External links

• Dermatology Advisor
• VisualDx

Notes and References

1. Book: Rapini, Ronald P. . Bolognia, Jean L. . Jorizzo, Joseph L. . Dermatology: 2-Volume Set . Mosby . St. Louis . 2007 . 978-1-4160-2999-1 .
2. Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). Page 562. McGraw-Hill. .
3. Bharti . Rakesh . Pemphigus Erythematosus: Practice Essentials, Etiology, Epidemiology . Medscape Reference . December 6, 2022 . February 4, 2024.
4. Oktarina . Dyah A. M. . Poot . Angelique M. . Kramer . Duco . Diercks . Gilles F. H. . Jonkman . Marcel F. . Pas . Hendri H. . The IgG "Lupus-Band" Deposition Pattern of Pemphigus Erythematosus . Archives of Dermatology . American Medical Association (AMA) . 148 . 10 . October 1, 2012 . 1173–1178 . 0003-987X . 10.1001/archdermatol.2012.1896 . 22801864 .
5. Lo Schiavo . Ada . Puca . Rosa Valentina . Romano . Francesca . Cozzi . Roberto . Pemphigus erythematosus relapse associated with atorvastatin intake . Drug Design, Development and Therapy . Informa UK Limited . 2014 . 8 . 1463–1465 . 1177-8881 . 10.2147/dddt.s66666 . free . 25258514 . 4173814 .
6. Kim . YoungJae . Yang . HeeJoo . Lee . WooJin . Won . ChongHyun . Chang . SungEun . Lee . MiWoo . Choi . JeeHo . A case of new-onset pemphigus erythematosus after topical application of ingenol mebutate . Indian Journal of Dermatology . Medknow . 66 . 5 . 2021 . 0019-5154 . 10.4103/ijd.ijd_820_20 . free . 563. 35068520 . 8751704 .
7. Ogata . Kimiko . Yasuda . Kayo . Matsushita . Mitsuji . Kodama . Hajime . Successful Treatment of Adolescent Pemphigus Vulgaris by Immunoadsorption Method . The Journal of Dermatology . Wiley . 26 . 4 . 1999 . 0385-2407 . 10.1111/j.1346-8138.1999.tb03463.x . 236–239. 10343469 . 22757265 .
8. Egan . Conleth A. . Meadows . Kappa P. . Zone . John J. . Plasmapheresis as a steroid saving procedure in bullous pemphigoid . International Journal of Dermatology . Wiley . 39 . 3 . 2000 . 0011-9059 . 10.1046/j.1365-4362.2000.00876.x . 230–235. 10759969 . 23582853 .