Togavirin Explained

Togavirin
Ec Number:3.4.21.90
Cas Number:342882-56-8

Togavirin (Sindbis virus protease, Sindbis virus core protein, NsP2 proteinase) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction

Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-Ser- bond

This enzyme is isolated from the Sindbis and Semliki forest togaviruses.

Notes and References

  1. Kräusslich HG, Wimmer E . Viral proteinases . Annual Review of Biochemistry . 57 . 701–54 . 1988 . 3052288 . 10.1146/annurev.bi.57.070188.003413 .
  2. Strauss EG, De Groot RJ, Levinson R, Strauss JH . Identification of the active site residues in the nsP2 proteinase of Sindbis virus . Virology . 191 . 2 . 932–40 . December 1992 . 1448929 . 10.1016/0042-6822(92)90268-t . 7131396 .
  3. Tong L, Wengler G, Rossmann MG . Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures . Journal of Molecular Biology . 230 . 1 . 228–47 . March 1993 . 8450538 . 10.1006/jmbi.1993.1139 .

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