| Simone Osygus | |
| Fullname: | Simone Osygus |
| Club: | SG Bochum-Wattenscheid |
| Birth Date: | 30 September 1968 |
| Birth Place: | Wuppertal, North Rhine-Westphalia, West Germany |
| Height: | 1.8m (05.9feet) |
| Weight: | 65kg (143lb) |
Simone Osygus (born 30 September 1968 in Wuppertal, Nordrhein-Westfalen) is a former freestyle swimmer from Germany, who won two silver medals and two bronze medals at the Summer Olympics.
Together with Franziska van Almsick, Daniela Hunger and Manuela Stellmach, she won the bronze medal in the 4×100 metres freestyle relay at the 1992 Summer Olympics in Barcelona, Spain. She won also a bronze medal in the same event at the 1996 Summer Olympics in Atlanta, this time with Van Almsick, Sandra Völker and Antje Buschschulte. She also won two silver medals in the 4×200 metres freestyle relay and 4×100 medley relay races, although she swam only in the heats.