Simon N. Powell Explained

Simon N. Powell
Birth Date:	13 February 1955
Birth Place:	Manchester, England
Nationality:	British/Permanent Resident in the U.S.
Fields:	Radiation Oncology and Breast Cancer Research
Workplaces:	Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center
Alma Mater:	Oxford University, U.K. (B.A.) 1976, The University of London, U.K. (M.B.B.S.) 1981, The University of London, U.K. (Ph.D.) 1991
Spouse:	Naomi Joshi

Simon N. Powell (born February 1955) is a British cancer researcher and radiation oncologist residing in New York City.

Biography

Powell was born on February 13, 1955, in Manchester, England. Powell received the Bachelor of Medicine, Bachelor of Surgery in 1981 from the University of London and went on to complete his Ph.D. there in 1991, holding residencies at Whittington Hospital and Hammersmith Hospital in London^[1] and a fellowship at the Royal Marsden Hospital before being recruited and settling in America.^[2]

Career

Powell held a fellowship at Harvard Medical School in 1991,^[3] becoming an instructor in 1992, and associate professor of radiation oncology in 1998. He then became clinical director of the Gillette Center for Women's Cancers,^[4] co-leader of the Harvard Breast Cancer Research Program, and leader of the DNA Repair/Radiation Biology Program. From 2004 to 2008 he served as professor and head of Radiation therapy/radiation oncology at the Washington University School of Medicine in St. Louis.

In 2008, Powell moved to New York to join Memorial Sloan Kettering Cancer Center and become the Chair of the Department of Radiation Oncology in Memorial Hospital^[5] with a joint appointment in Sloan Kettering Institute's Molecular Biology Program.^[6] He was also appointed to the faculties of the Gerstner Sloan Kettering Graduate School of Biomedical Science^[7] and Weill Cornell Graduate School of Medical Sciences.^{[8] [9]} He also holds the Enid A. Haupt Chair in Radiation Oncology at the Center.^[10] His career has centered on understanding DNA repair alterations in cancer and how they can be used for the basis of selective cancer therapies. His clinical expertise is in the treatment of breast cancer.^[11]

Memberships and significant positions

• Fellow of the Royal College of Radiologists of the United Kingdom^[12]
• Associate editor, International Journal of Cancer for eight years
• Associate editor, Radiation Research for 5 years^[13]
• Editorial board of the Journal of Cancer Biology and Therapy (now the International Journal of Cancer)^[14]
• Member, American Association for Cancer Research^[15]
• Member, Radiation Research Society^[16]

Awards

• Fellow of the American Society for Radiation Oncology (FASTRO) 2014^[17]
• European Society for Theapeutic Radiology and Oncology (E.S.T.R.O.) Varian Award (1990)^[18]

Selected publications

• 7712468 . 1995 . Powell . Simon N. . Defrank . Jeffrey S. . Connell . Paul . Eogan . Maeve . Preffer . Frederic . Dombkowski . David . Tang . Wei . Friend . Stephen . Differential sensitivity of p53^(-) and p53⁽⁺⁾ cells to caffeine-induced radiosensitization and override of G2 delay . 55 . 8 . 1643–8 . Cancer Research .
• 1847–57. 10.1038/sj.onc.1201143. Inactivation of p53 results in high rates of homologous recombination. 1997. Mekeel. Kristin L. Tang. Wei. Kachnic. Lisa A. Luo. Chen-Mei. Defrank. Jeffrey S. Powell. Simon N. Oncogene. 14. 15. 9150391. 25122282.
• 8644–9. 10.1073/pnas.151253498. 37489. Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining. Powell. S.N.. 2001. Xia. F.. Taghian. D.G.. DeFrank. J.S.. Zeng. Z.C.. Willers. H.. Iliakis. G.. Proceedings of the National Academy of Sciences. 98. 15. 11447276. 2001PNAS...98.8644X. free.
• 14701743 . 2004 . Zhang . J . Willers . H . Feng . Z . Ghosh . JC . Kim . S . Weaver . DT . Chung . JH . Powell . SN . Xia . F . Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair . 24 . 2 . 708–18 . 343805 . Molecular and Cellular Biology . 10.1128/MCB.24.2.708-718.2004.
• 9025–33 . 10.1038/sj.onc.1207982 . The interaction of p53 with replication protein a mediates suppression of homologous recombination . 2004 . Romanova . Larisa Y . Willers . Henning . Blagosklonny . Mikhail V . Powell . Simon N . Oncogene . 23 . 56 . 15489903.
• 255–65 . 10.1016/j.ccr.2005.08.004 . BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ . 2005 . Litman . Rachel . Peng . Min . Jin . Zhe . Zhang . Fan . Zhang . Junran . Powell . Simon . Andreassen . Paul R. . Cantor . Sharon B. . Cancer Cell . 8 . 3 . 16153896. free .
• 902–9 . 10.1038/nsmb991 . MDC1 interacts with Rad51 and facilitates homologous recombination . 2005 . Zhang . Junran . Ma . Zhefu . Treszezamsky . Alejandro . Powell . Simon N . Nature Structural & Molecular Biology . 12 . 10 . 16186822. 24097999 .
• 686–91 . 10.1073/pnas.1010959107 . Rad52 inactivation is synthetically lethal with BRCA2 deficiency . 2010 . Feng . Z. . Scott . S. P. . Bussen . W. . Sharma . G. G. . Guo . G. . Pandita . T. K. . Powell . S. N. . Proceedings of the National Academy of Sciences . 108 . 2 . 21148102 . 3021033. free .
• 668–72 . 10.1038/ng.855 . The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma . 2011 . Bott . Matthew . Brevet . Marie . Taylor . Barry S . Shimizu . Shigeki . Ito . Tatsuo . Wang . Lu . Creaney . Jenette . Lake . Richard A . Zakowski . Maureen F . 8 . Nature Genetics . 43 . 7 . 21642991. 4643098 .
• Riaz . N . Blecua . P . Lim . RS . Shen . R . Higginson . DS . Weinhold . N . Norton . L . Weigelt . B . Powell . SN . Reis-Filho . JS . Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes. . Nature Communications . 11 October 2017 . 8 . 1 . 857 . 10.1038/s41467-017-00921-w . 29021619. 5636842 . 2017NatCo...8..857R .
• Bakhoum . SF . Ngo . B . Laughney . AM . Cavallo . JA . Murphy . CJ . Ly . P . Shah . P . Sriram . RK . Watkins . TBK . Taunk . NK . Duran . M . Pauli . C . Shaw . C . Chadalavada . K . Rajasekhar . VK . Genovese . G . Venkatesan . S . Birkbak . NJ . McGranahan . N . Lundquist . M . LaPlant . Q . Healey . JH . Elemento . O . Chung . CH . Lee . NY . Imielenski . M . Nanjangud . G . Pe'er . D . Cleveland . DW . Powell . SN . Lammerding . J . Swanton . C . Cantley . LC . Chromosomal instability drives metastasis through a cytosolic DNA response. . Nature . 25 January 2018 . 553 . 7689 . 467–472 . 10.1038/nature25432 . 29342134. 5785464 . 2018Natur.553..467B .

External links

• Publications: Simon N. Powell's Publications
• Pubmed: Simon N. Powell's Journal Articles
• An Interview with Simon Powell

Notes and References

1. Web site: Dr. Simon Powell - Radiation Oncology - New York, NY. www.castleconnolly.com. 2018-10-09.
2. Web site: Simon Powell to Lead Department of Radiation Oncology. Barnes Jewish Hospital. Washington University School of Medicine in St. Louis . July 13, 2004. https://web.archive.org/web/20150905224404/http://www.siteman.wustl.edu/ContentPage.aspx?id=522. September 5, 2015. dead. Retrieved January 9, 2013
3. 2004-05-07. Simon Powell Moving to Head Radiation Oncology at Washington University. Cancer Biology & Therapy. en. 3. 8. 699–707. 10.4161/cbt.3.8.1108. 1538-4047. free.
4. 2004. Awards, Appointments, Announcements. J Natl Cancer Inst . 96. 16. 1203. 10.1093/jnci/96.16.1203. free.
5. News: Radiation Bills Raise Question of Supervision. Bogdanich. Walt. Jan 14, 2013. The New York Times. Feb 25, 2010.
6. Web site: Simon Powell Named Chair of Radiation Oncology. https://web.archive.org/web/20151231110243/http://www2.mskcc.org/gerstner/html/86734.cfm. 2015-12-31. dead. December 31, 2015. Retrieved January 10, 2013
7. Web site: Faculty Gerstner Sloan Kettering Graduate School of Biomedical Sciences . www.sloankettering.edu . 5 October 2018 . en.
8. Web site: Weill Cornell Graduate School of Medical Sciences, Cornell University, Our Faculty. dead. https://web.archive.org/web/20121222190300/http://weill.cornell.edu:80/gradschool/faculty/index.html. December 22, 2012.
9. Web site: Weill Cornell Graduate School of Medical Sciences, Cornell University. Biochemistry & Structural Biology, Cell & Developmental Biology, and Molecular Biology Overview. dead. https://web.archive.org/web/20121118011720/http://weill.cornell.edu:80/gradschool/program/molecular.html. November 18, 2012.
10. Web site: Simon N. Powell Memorial Sloan Kettering Cancer Center. www.mskcc.org. en. 2018-10-06.
11. Book: Evolution of Radiation Oncology at Massachusetts General Hospital. Suit. Herman D.. Loeffler. Jay S.. 2011-02-04. Springer Science & Business Media. 9781441967442. 141. en.
12. Web site: Simon N. Powell, M.D., Ph.D., Department of Radiation Oncology, Chairman. Washington University School of Medicine. Jan 14, 2013. dead. https://web.archive.org/web/20160304075220/http://radonc.wustl.edu/clinical/powell.html. March 4, 2016.
13. http://www.kumc.edu/rrsnews/archives/2001/2001-2/AnnualReport.htm Radiation Research Society News Annual Report - Radiation Research 2000
14. Web site: Landes Bioscience, Cancer Biology & Therapy Journal, Editorial Board. dead. https://web.archive.org/web/20141001052305/http://www.landesbioscience.com:80/journals/cbt/editorialboard/. October 1, 2014.
15. Lok. BH. Powell. SN. Molecular Pathways: Understanding the Role of Rad52 in Homologous Recombination for Therapeutic Advancement. Clinical Cancer Research. American Association for Cancer Research. 18. 23. 6400–6406. 10.1158/1078-0432.CCR-11-3150. 3513650. 23071261. 2012. P. 7
16. Web site: 56th Annual Meeting, Radiation Research Society, Oceans of Opportunity. Synthetic Lethality and Repair Targeting: New Opportunities for Treatment. Radiation Research Society. Jan 14, 2013. dead. https://web.archive.org/web/20120515100013/http://www.radres.org/ECOMradres/timssnet/RadeFTP/RRS_2010_Abstract.pdf. May 15, 2012.
17. Web site: Fellow Recipients - American Society for Radiation Oncology (ASTRO) - American Society for Radiation Oncology (ASTRO). ASTRO. 2018-10-06.
18. Web site: ESTRO - Varian Research Award. Clonal variation of DNA repair in a human glioma cell line. Institute of Cancer Research, Sutton, Surrey, UK. Jan 14, 2013. dead. https://web.archive.org/web/20120330231132/http://www.estro.org/about/Pages/estroorgaboutPagesESTROAwardsVarian.aspx. March 30, 2012.