| Honorific Prefix: | The Right Honourable |
| Simon Mayne | |
| Term Start1: | 6 April 1691 |
| Term End1: | 28 January 1696 |
| Term Start2: | 1705 |
| Term End2: | 1710 |
| Birth Date: | circa. 1644 |
| Birth Place: | Dinton, Buckinghamshire, England |
| Death Date: | 1725 |
| Resting Place: | Dinton, Buckinghamshire |
| Spouse: | Elizabeth Browne |
| Mother: | Elizabeth |
Simon Mayne (c. 1644 – 1725) was MP for Aylesbury from 6 April 1691 to 28 January 1696 and again from 1705 to 1710.