Simmerafil Explained

Legal Status:	Investigational
Cas Number:	1229018-87-4
Pubchem:	136197286
Synonyms:	TPN171
Iupac Name:	N-[3-(4,5-Diethyl-6-oxo-1''H''-pyrimidin-2-yl)-4-propoxyphenyl]-2-(4-methylpiperazin-1-yl)acetamide
C:	24
H:	35
N:	5
O:	3

Simmerafil^[1] (TPN171H) is a selective PDE5 inhibitor^[2] in development for the treatment of erectile dysfunction^[3] and pulmonary hypertension.^[4]

Notes and References

1. Odilov . Abdullajon . Liu . Yin . Hu . Tianwen . Jiang . Xiangrui . Suo . Jin . Tian . Guanghui . Yang . Feipu . Shen . Jingshan . Facile and Cost-Effective Route for the Synthesis of Simmerafil . Organic Process Research & Development . 19 November 2021 . 25 . 11 . 2432–2437 . 10.1021/acs.oprd.1c00184 . 244619662 . en . 1083-6160.
2. Qian . Hongjie . Chen . Qian . Liang . Liyu . Zou . Yang . Pu . Huahua . Xin . Liang . Song . Rong . Li . Tingting . Zhu . Huijuan . Wang . Yu . Tian . Guanghui . Shen . Jingshan . Jiang . Hualiang . Yu . Chen . Wang . Zhen . Jia . Jingying . A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects . Drug Design, Development and Therapy . 2021 . 15 . 2947–2959 . 10.2147/DDDT.S308610 . 34262260 . 8273902 . 1177-8881 . free .
3. Web site: Efficacy and Safety Study of TPN171H Tablets in Erectile Dysfunction . www.clinicaltrials.gov . CTG Labs . 9 November 2023.
4. Zhao . Congke . Hu . Liqing . He . Xiangrong . Li . Lijun . Yin . Minghui . Tettey . Abraham Terkpertey . Wang . Yu . Shen . Jingshan . Tang . Siyuan . Wu . Chunhui . Li . Qianbin . Wang . Zhen . Li . Xiaohui . TPN171H alleviates pulmonary hypertension via inhibiting inflammation in hypoxia and monocrotaline-induced rats . Vascular Pharmacology . 1 August 2022 . 145 . 107017 . 10.1016/j.vph.2022.107017 . 35680060 . 249490064 . 1537-1891.