Simfibrate Explained

Simfibrate (JAN/INN; trade name Cholesolvin) is a fibrate that has been used for the treatment of hyperlipidemia.[1] [2] The substance is a double ester of clofibric acid with 1,3-propanediol which is cleaved in the body to one molecule of 1,3-propanediol and two molecules of clofibric acid which is the true lipid-lowering agent.

Notes and References

  1. 10.22159/ijcpr.2017v9i1.16616 . Introduction to Hyperlipidemia and its Treatment: A Review . International Journal of Current Pharmaceutical Research . 9 . 6 . 2016 . Verma . Niharika . vanc . free .
  2. Olsson AG, Orö L, Rössner S . Clinical and metabolic effects of pentaerythritol tetranicotinate in combination with cholesolvin or clofibrate . Atherosclerosis . 19 . 3 . 407–15 . 1974 . 4364073 . 10.1016/S0021-9150(74)80005-5 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Simfibrate".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.