| Simeón Oyono | |
| Office: | Minister of Foreign Affairs and International Cooperation |
| Term Start: | 2018 |
| Predecessor: | Agapito Mba Mokuy |
| Birth Name: | Simeón Oyono Esono Angüe |
| Birth Date: | 18 February 1967 |
| Birth Place: | Mibang Esawong, Spanish Guinea[1] |
| Party: | Democratic Party of Equatorial Guinea |
Simeón Oyono Esono Angüe (born 18 February 1967) is an Equatorial Guinean politician who has been Minister of Foreign Affairs and International Cooperation since 2018.[2]