Sign of Hertoghe explained

Synonym:	Queen Anne's sign
Differential:	hypothyroidism

The Sign of Hertoghe or Queen Anne's sign is a thinning or loss of the outer third of the eyebrows, and is a classical sign of hypothyroidism or atopic dermatitis,^[1] but it can also be detected in lepromatous leprosy.^[2] The sign is named after the Belgian Internist Eugene Ludovic Christian Hertoghe (April 5, 1860–January 3, 1928), who was a native of Antwerp, and was the first pioneer in thyroid function research.^{[3] [4] [5]} __TOC__

Queen Anne's sign

The association with Anne of Denmark is based on portraiture, although history does not suggest that she suffered an underactive thyroid.^[6] The eponym is disputed by some, though it has been suggested that Anne of France, Anne of Brittany, Anne of Austria, Anne Boleyn and Anne of Cleves may all be eliminated as candidates.^[7]

Notes and References

1. Ständer . Sonja . Atopic Dermatitis . New England Journal of Medicine . 2021-03-25 . 384 . 12 . 1136–1143 . 10.1056/NEJMra2023911. 33761208 . 232355341 .
2. Parrino . Daniela . Di Bella . Stefano . 2016-03-29 . Hertoghe sign: an hallmark of lepromatous leprosy . QJM: Monthly Journal of the Association of Physicians . 1460-2393 . 10.1093/qjmed/hcw046 . 27026695 . 109 . 7 . 497. free .
3. Schatz . Henry A. . May 1922 . The Role of the Thyroid Gland in Otolaryngology . The Pennsylvania Medical Journal . 25 . 8 . 529.
4. April 1914 . Complimentary Dinner given by Dr. William Seaman Bainbridge . American Medicine . 9 . 4 . 308 . 2014-12-12.
5. Web site: Eugène Ludovic Christian Hertoghe (1860-1928) » van Lerberghe genealogy » Genealogy Online.
6. Lane Furdell E . May 2007 . Eponymous, anonymous: Queen Anne's sign and the misnaming of a symptom . J Med Biogr . 17551609 . 10.1258/j.jmb.2007.06-13. 15 . 2 . 97–101 . 2474437 . subscription .
7. Keynes . M . February 2009 . Letter to the editor . J Med Biogr . 19190203 . 10.1258/jmb.2007.007021 . 17 . 1 . 62 . 207200169 .