| Sierra de Santa Cruz | |
| Country: | Guatemala |
| District Type: | Department |
| District: | Izabal |
| Settlement Type: | Municipality |
| Period: | Mesozoic (Cretaceous) |
| Length Km: | 55 |
| Length Orientation: | south-west to north-east |
| Width Km: | 13 |
| Highest Location: | Guatemala |
| Elevation M: | 1100 |
| Coordinates: | 15.6811°N -89.3269°W |
| Map: | Guatemala |
The Sierra de Santa Cruz is a small mountain range in eastern Guatemala. It is situated north of Lake Izabal, in the department of Izabal. The mountain range has a south-west to north-east orientation, and is approximately 55 km long and 13 km wide.[1] Its highest peaks have an altitude of approximately 1100 m (15.6812°N -89.3269°W).
Craugastor trachydermus, a species of frog in the family Craugastoridae, is endemic to Guatemala and only known from its type locality, Xiacam in the Sierra de Santa Cruz. It is critically endangered.