| Conflict: | Siege of Musashi-Matsuyama |
| Partof: | the Sengoku period |
| Date: | 1537 |
| Place: | Matsuyama Castle, Musashi province |
| Result: | Siege successful, castle falls to Hōjō |
| Combatant1: | Uesugi clan garrison |
| Combatant2: | Hōjō forces |
| Commander1: | Uesugi Tomooki Nanbada Norishige |
| Commander2: | Hōjō Ujitsuna Hōjō Genan Hōjō Tsunashige |
| Strength2: | 7,000 men |
The 1537 siege of Musashi-Matsuyama was the first of several sieges of Matsuyama castle in Japan's Musashi province over the course of the Sengoku period (1467-1603). The Uesugi clan controlled the castle in 1537, but lost it to the Hōjō clan in this siege; they would regain it, and lose it once more in 1563.
The Uesugi sent for help during this siege by hiding a message inside a dog's collar; the tactic was ultimately unsuccessful.