| Conflict: | Siege of Miletus |
| Partof: | the Wars of Alexander the Great |
| Coordinates: | 37.5303°N 27.2783°W |
| Map Type: | Turkey |
| Map Relief: | y |
| Map Size: | 300 |
| Map Label: | Miletus |
| Date: | 334 BC |
| Place: | Miletus, Ionia (modern-day Balat, Didim, Aydın Province, Turkey) |
| Territory: | Alexander controls Ionia |
| Result: | Macedonian victory |
| Combatant1: | |
| Combatant2: | Achaemenid Empire Milesian allies |
| Commander1: | Alexander the Great Nicanor Hephaestion |
| Commander2: | Hegesistratus |
| Strength1: | 160 ships |
| Strength2: | 400 ships (not engaged) 300 Milesians |
| Casualties1: | Light |
| Casualties2: | Heavy |
The siege of Miletus was Alexander the Great's first siege and naval encounter with the Achaemenid Empire. This siege was directed against Miletus, a city in southern Ionia, which is now located in the Aydın province of modern-day Turkey. During the battle, Parmenion's son Philotas would be key in preventing the Persian Navy from finding safe anchorage.[1] It was captured by Parmenion's son, Nicanor in 334 BC.