| Conflict: | Siege of Malacca |
| Partof: | the Dutch–Portuguese War, Malay–Portuguese conflicts |
| Date: | 1606 |
| Place: | Portuguese Malacca |
| Result: | Portuguese victory |
| Combatant1: |  Portugal |
| Casualties1: | Unknown |
| Casualties2: | Unknown |
The siege of Malacca of 1606 was a military engagement between a Dutch force commanded by Cornelis Matelief and the Portuguese commander André Furtado de Mendonça.
The small Portuguese garrison managed to hold out and stop any Dutch direct attacks on the city until additional reinforcements led by Martim Afonso de Castro arrived, which caused the Dutch to retreat from the siege. After they retreated, they were again defeated by the Portuguese at the Battle of Cape Rachado.