| Conflict: | Siege of Antioch (253) |
| Partof: | the Roman-Persian wars |
| Date: | 253 |
| Place: | Antioch (modern-day Antakya, Hatay, Turkey) |
| Result: | Sassanid victory[1] |
| Combatant1: | Roman Empire |
| Combatant2: | Sassanid Empire |
| Commander2: | Shapur IHormizd I |
| Strength1: | unknown |
| Strength2: | unknown |
The siege of Antioch took place when the Sassanids under Shapur I besieged the Roman city of Antioch in 253 after defeating the Romans in the Battle of Barbalissos.
Glanville, Downey (1961). A History of Antioch in Syria from Seleucus to the Arab Conquest. 10.8 pp. 252-259, 587