Sibiromycin Explained

Sibiromycin is an antitumor antibiotic with the molecular formula C₂₄H₃₃N₃O₇ which is produced by the bacterium Streptosporangium sibiricum.^{[1] [2] [3]} Sibiromycin is a pyrrolobenzodiazepine.^{[4] [5]}

Further reading

• Book: Kersten . H. . Kersten . W. . Inhibitors of Nucleic Acid Synthesis: Biophysical and Biochemical Aspects . 11 November 2013 . Springer Science & Business Media . 978-3-642-80855-5 . 19 . en.
• Book: Corcoran . John W. . Biosynthesis . 6 December 2012 . Springer Science & Business Media . 978-3-642-67724-3 . 277 . en.
• Book: Comprehensive Natural Products III . 22 July 2020 . Elsevier . 978-0-08-102691-5 . 412 . en.

Notes and References

1. Book: Gause . G. F. . Mechanism of Action of Antimicrobial and Antitumor Agents . Sibiromycin . 1975 . 269–273 . 10.1007/978-3-642-46304-4_17. 978-3-642-46306-8 .
2. Li . Wei . Khullar . Ankush . Chou . ShenChieh . Sacramo . Ashley . Gerratana . Barbara . Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic . Applied and Environmental Microbiology . May 2009 . 75 . 9 . 2869–2878 . 10.1128/AEM.02326-08. 19270142 . 2681668 . 2009ApEnM..75.2869L .
3. Book: Rhoads . Robert E. . Proceedings of the Research Symposium on Complexes of Biologically Active Substances with Nucleic Acids and Their Modes of Action: Held at the Walter Reed Army Institute of Research Washington, 16–19 March 1970 . 6 December 2012 . Springer Science & Business Media . 978-3-642-65141-0 . 33 . en.
4. Book: Antibiotics and Chemotherapy . 1980 . S. Karger . 978-3-8055-2830-6 . 105 . en.
5. Book: Rahman . Khondaker Miraz . Thurston . David E. . Small-Molecule Transcription Factor Inhibitors in Oncology . 6 September 2018 . Royal Society of Chemistry . 978-1-78262-145-4 . 87 . en.