Sibiricine Explained

Sibiricine is a bioactive isoquinoline alkaloid isolated from Corydalis crispa (Fumariaceae), which is a Bhutanese medicinal plant from the Himalayas.^{[1] [2]}

Using high resolution mass spectrometry, the molecular formula of sibiricine is determined to be C₂₀H₁₇NO₆.^[3] The IUPAC name for sibiricine is 8'-hydroxy-6-methylspiro[7,8-dihydro-[1,3]dioxolo[4,5-''g'']isoquinoline-5,7'-8H-cyclopenta[''g''][1,3]benzodioxole]-6'-one. The proton nuclear magnetic resonance (PMR) spectrum of sibiricine at 100 MHz shows that sibiricine is structurally related to ochrobirine and ochotensine.^[3] With the exception of sibiricine, 8 other alkaloids are extracted by investigating Corydalis crispa. These isoquinoline alkaloids are protopine, 13-oxoprotopine, 13-oxocryptopine, stylopine, coreximine, rheagenine, ochrobirine, and bicuculline.

Notes and References

1. 22799079 . 2012 . Wangchuk . P. . Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa . Natural Product Communications . 7 . 5 . 575–80 . Keller . P. A. . Pyne . S. G. . Sastraruji . T. . Taweechotipatr . M. . Rattanajak . R. . Tonsomboon . A. . Kamchonwongpaisan . S. . 10.1177/1934578X1200700507 . free .
2. 10.1038/srep32101. 27572696. 5004179. Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms. Scientific Reports. 6. 32101. 2016. Wangchuk. Phurpa. Giacomin. Paul R.. Pearson. Mark S.. Smout. Michael J.. Loukas. Alex. 2016NatSR...632101W.
3. 10.1139/v69-592 . Structure of sibiricine, an alkaloid of Corydalissibirica . Canadian Journal of Chemistry . 47 . 19 . 3585–3588 . 1969 . Manske . R. H. F. . Rodrigo . R. . MacLean . D. B. . Gracey . D. E. F. . Saunders . J. K. . free .