Sialidase-2 Explained

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.^{[1] [2] [3]}

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS-7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.^[3]

Further reading

• Li CY . A nonsynonymous SNP in human cytosolic sialidase in a small Asian population results in reduced enzyme activity: potential link with severe adverse reactions to oseltamivir . Cell Res. . 17 . 4 . 357–362 . 2007 . 17426694 . 10.1038/cr.2007.27 . Yu Q . Ye ZQ . Sun . Ying . He . Quanyuan . Li . Xiao-Mo . Zhang . Wuxue . Luo . Jingchu . Gu . Xiaocheng . free .
• Chavas LM . Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognition . J. Biol. Chem. . 280 . 1 . 469–75 . 2005 . 15501818 . 10.1074/jbc.M411506200 . Tringali C . Fusi P . Venerando . B . Tettamanti . G . Kato . R . Monti . E . Wakatsuki . S . free.
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Hart ML . High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1 . AIDS Res. Hum. Retroviruses . 18 . 17 . 1311–1317 . 2003 . 12487819 . 10.1089/088922202320886352 . Saifuddin M . Uemura K . Bremer . Eric G. . Hooker . Brad . Kawasaki . Toshisuke . Spear . Gregory T. .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Bassi MT . SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family . Genomics . 62 . 2 . 297–303 . 2000 . 10610726 . 10.1006/geno.1999.5978 . Sperandeo MP . Incerti B . Bulfone . A . Pepe . A . Surace . EM . Gattuso . C . De Grandi . A . Buoninconti . A .
• Monti E . Expression of a novel human sialidase encoded by the NEU2 gene . Glycobiology . 9 . 12 . 1313–1321 . 2000 . 10561456 . 10.1093/glycob/9.12.1313 . Preti A . Nesti C . Ballabio . A . Borsani . G . free.
• Hu H . Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface . J. Virol. . 70 . 11 . 7462–70 . 1996 . 8892864 . 10.1128/JVI.70.11.7462-7470.1996. 190813 . Shioda T . Moriya C . Xin . X . Hasan . MK . Miyake . K . Shimada . T . Nagai . Y .
• Miyagi T . Molecular cloning and expression of cDNA encoding rat skeletal muscle cytosolic sialidase . J. Biol. Chem. . 268 . 35 . 26435–40 . 1994 . 8253770 . Konno K . Emori Y . Kawasaki . H . Suzuki . K . Yasui . A . Tsuik . S . 10.1016/S0021-9258(19)74333-6 . free .

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Sialidase-2

Notes and References

1. Monti E, Preti A, Rossi E, Ballabio A, Borsani G . Cloning and characterization of NEU2, a human gene homologous to rodent soluble sialidases . Genomics . 57 . 1 . 137–143 . Jun 1999 . 10191093 . 10.1006/geno.1999.5749 .
2. Tringali C, Papini N, Fusi P, Croci G, Borsani G, Preti A, Tortora P, Tettamanti G, Venerando B, Monti E . Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules . J Biol Chem . 279 . 5 . 3169–3179 . Jan 2004 . 14613940 . 10.1074/jbc.M308381200 . free .
3. Web site: Entrez Gene: NEU2 sialidase 2 (cytosolic sialidase).