Sho-saiko-to explained

, also known as minor bupuleurum formula and xiǎocháihútāng (XCHT), is a herbal supplement, believed to enhance liver health. Sho-Saiko-To is a widely used prescription drug in China and is a listed formula in China and Japan as a Kampo medicine. There are currently ongoing clinical trials for Sho-Saiko-To at University of California, San Diego and Memorial Sloan-Kettering Cancer Center. The active ingredients of sho-saiko-to discovered so far include baicalin, baicalein, glycyrrhizin, saikosaponins, ginsenosides, wogonin, and gingerol.

As a Chinese patent medicine it is listed in the Pharmacopoeia of the People's Republic of China. One dried, soluble form lists chai-hu/saiko (dried Bupleurum chinense or scorzonerifolium root), huangqin (dry Scutellaria baicalensis stem), banxia (Pinellia ternata), ginger, licorice, jujube, and Codonopsis pilosula as ingredients. This form is standardized to contain at least 20 mg baicalin per serving.[1] Some formulae use ginseng instead of C. pilosula.[2]

It is first recorded in Shanghan Lun, indicated for "lesser yang".[3] [4] It has some antidepressant-like effects.[5] [6] [7] [8]

Sho-saiko-to has been studied, but the results in patients with hepatitis B were very low.[9]

Further reading

Notes and References

  1. Book: 中国药典. 小柴胡颗粒. 576. 978-7-5067-7337-9. 1.
  2. 方剂学，段富津主编，上海科学技术出版社，1995.6.
  3. Zhu. Zhenyu. Zhao. Liang. Liu. Xiaofan. Chen. Jun. Zhang. Hai. Zhang. Guoqing. Chai. Yifeng. Comparative pharmacokinetics of baicalin and wogonoside by liquid chromatography–mass spectrometry after oral administration of Xiaochaihu Tang and Radix scutellariae extract to rats. Journal of Chromatography B. August 2010. 878. 24. 2184–2190. 10.1016/j.jchromb.2010.06.021. 20643590.
  4. DAI. Jie-yu. YANG. Jun-ling. LI. Chuan. Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu-tang across human intestinal Caco-2 cell monolayers. Acta Pharmacologica Sinica. September 2008. 29. 9. 1086–1093. 10.1111/j.1745-7254.2008.00850.x. 18718184. free.
  5. Li, F. M., & Gao, Z. G. (1996). 90 cases of xiaochaihutang treatment for depression in clinical. Shanxi J.Traditional Chin.Med., 10-11."
  6. Jia et al., 2009 C.X. Jia, K.F. Zhang, L. Yu, G.Q. Sun Antidepressant-like effects of Xiaochaihutang on Post stroke depression in clinical Zhejiang J. Tradit. Chin. Med., 44 (2009), pp. 105–106
  7. Su. Guang Yue. Yang. Jing Yu. Wang. Fang. Ma. Jie. Zhang. Kuo. Dong. Ying Xu. Song. Shao Jiang. Lu. Xiu Mei. Wu. Chun Fu. Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress. Journal of Ethnopharmacology. February 2014. 152. 1. 217–226. 10.1016/j.jep.2014.01.006. 24440317.
  8. Su. Guang Yue. Yang. Jing Yu. Wang. Fang. Xiong. Zhi Li. Hou. Yue. Zhang. Kuo. Song. Cui. Ma. Jie. Song. Shao Jiang. Teng. Huai Feng. Wu. Chun Fu. Xiaochaihutang prevents depressive-like behaviour in rodents by enhancing the serotonergic system. Journal of Pharmacy and Pharmacology. January 2014. 66. 6. 823–34. 10.1111/jphp.12201. 24359306. 20187116 . free.
  9. Kong. De Zhao. Liang. Ning. Yang. Guan Lin. Zhang. Zhe. Liu. Yue. Li. Jing. Liu. Xuehan. Liang. Shibing. Nikolova. Dimitrinka. Jakobsen. Janus C. Gluud. Christian. 2019-11-07. Cochrane Hepato-Biliary Group. Xiao Chai Hu Tang, a herbal medicine, for chronic hepatitis B. Cochrane Database of Systematic Reviews. 2019 . 11 . en. 10.1002/14651858.CD013090.pub2. 6953322. 31697415.

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