Shirley is an unincorporated community in Washington County, in the U.S. state of Missouri.
The community is on Missouri Route 8 approximately six miles west of Potosi. Allen Branch flows through the community and enters the Sunnen Reservoir one mile to the north.[1]
A post office called Shirley was established in 1894, and remained in operation until 1955.[2] The community has the name of James Shirley, a local merchant.[3]
Susan Cave (23WA190) was listed on the National Register of Historic Places in 1989.