| Shelburne River | |
| Pushpin Map: | Nova Scotia |
| Pushpin Map Caption: | Location of mouth |
| Subdivision Type1: | Country |
| Length: | 53km (33miles) |
| Basin Size: | 277.39km2 |
The Shelburne River is a 53 km long river in Nova Scotia, Canada. It is a wilderness river and is a tributary of Mersey River. It starts in the Tobeatic Wilderness Area.
The Shelburne River was designated a Canadian Heritage River in 1997.