| Shaykh Issa | |
| Native Name: | الشيخ عيسى |
| Native Name Lang: | ar |
| Type: | Town |
| Pushpin Map: | Syria |
| Pushpin Label Position: | bottom |
| Pushpin Mapsize: | 250 |
| Pushpin Map Caption: | Location of Shaykh Issa in Syria |
| Subdivision Type: | Country |
| Subdivision Type1: | Governorate |
| Subdivision Name1: | Aleppo |
| Subdivision Type2: | District |
| Subdivision Name2: | Azaz |
| Subdivision Type3: | Subdistrict |
| Subdivision Name3: | Tell Rifaat |
| Population: | 4296 |
| Population Density Km2: | auto |
| Population As Of: | 2004 |
| Timezone: | EET |
| Utc Offset: | +2 |
| Timezone Dst: | EEST |
| Utc Offset Dst: | +3 |
| Geocode: | C1624 |
Shaykh Issa (Arabic: الشيخ عيسى) is a town in northern Aleppo Governorate, northwestern Syria. Located north of Aleppo, it is administratively part of Nahiya Tell Rifaat in A'zaz District. Nearby localities include Tell Rifaat to the west, Kaljibrin to the north and Mare' to the east. In the 2004 census, Shaykh Issa had a population of 4,296. The town is at 36.47926 ° N 37.14506 ° E