Sheena Josselyn Explained

Sheena Josselyn
Birth Place:Cleveland, Ohio
Nationality:Canadian
Fields:Neuroscience
Workplaces:SickKids at the University of Toronto
Alma Mater:Queens University, University of Toronto
Known For:Engrams
Awards:Daniel H. Efron Research Award from American College of Neuropsychopharmacology, Innovations in Psychopharmacology Award from Canadian College of Neuropsychopharmacology, Brenda Milner Lecturer (University of Lethbridge), Bryan Kolb Lecturer in Behavioural Neuroscience (University of Calgary), Canada Research Chair (CRC) in brain circuits and cognition Tier I
Spouse:Paul Frankland

Sheena Josselyn is a Canadian neuroscientist and a full professor of psychology and physiology at Hospital for Sick Children and The University of Toronto.[1] [2] Josselyn studies the neural basis of memory, specifically how the brain forms and stores memories in rodent models. She has made critical contributions to the field of Neuronal Memory Allocation and the study of engrams.[3]

Early life and education

Josselyn was born in Cleveland, Ohio but grew up in Kingston, Ontario, Canada.[4] Josselyn completed her undergraduate education at Queens University in Kingston, Ontario, Canada. Following her undergraduate degree, Josselyn completed a master's degree in clinical psychology under the mentorship of Dr. Rick Beninger. In her Masters, Josselyn published two first author papers, the first studying the modulatory effects of adenosine on dopamine in the striatum[5] and the second on the interaction between neuropeptide Y and antipsychotics in the nucleus accumbens.[6]

Josselyn then moved to Toronto to complete her PhD in psychology and neuroscience at the University of Toronto. Under the mentorship of Dr. Franco Vaccarino, Josselyn studied the effects of CCKB and CCKA modulation on associative learning and published multiple first author papers.[7] [8] [9] Following her PhD, Josselyn completed her postdoctoral work at Yale University in New Haven under the mentorship of Dr. Mike Davis.[10] Shortly after, she moved to LA to complete another postdoc under the mentorship of Dr. Alcino J. Silva at the University of California Los Angeles. Josselyn helped discover the importance of CREB in memory formation and retrieval[11] which led to probing the molecular mechanisms and biological purpose of forgetting.[12]

Career and research

After finishing her postdoctoral work, Josselyn moved back to Toronto to start her lab at SickKids Hospital at the University of Toronto. Her overall goal is to understand how humans learn and remember such that one day her work can impact translational research at her institute and in her community. Some of Josselyn's early discoveries include discovering that CREB over-expression in the auditory thalamus increases memory and fear,[13] and further, that ablating neurons that highly expressed CREB after fear learning actually ablates fear memories in rodent.[14] These were some of the first findings isolating specific neurons representing a specific memory in the brain.[15] Josselyn's multidisciplinary approach to tackling questions regarding memories led her to several prestigious awards and recognitions including becoming a member of the Royal Society of Canada in 2018 for her research.[16]

Awards

Publications

Notes and References

  1. Web site: Department of Physiology. www.physiology.utoronto.ca. 2020-03-26.
  2. Web site: Sheena Josselyn*. www.neuroscience.utoronto.ca. 2020-03-26.
  3. Web site: Cynthia . Macdonald . The memory hunters . Canadian Institute for Advanced Research (CIFAR) . 25 March 2022 . 23 May 2019.
  4. Web site: Profile of Sheena Josselyn. Children. The Hospital for Sick. www.sickkids.ca. en. 2020-03-26.
  5. Josselyn. Sheena A.. Beninger. Richard J.. 1991-05-01. Behavioral effects of intrastriatal caffeine mediated by adenosinergic modulation of dopamine. Pharmacology Biochemistry and Behavior. en. 39. 1. 97–103. 10.1016/0091-3057(91)90403-O. 1924519. 12144897. 0091-3057.
  6. Josselyn. Sheena A.. Beninger. Richard J.. 1993-11-01. Neuropeptide Y: Intraaccumbens injections produce a place preference that is blocked by cis-flupenthixol. Pharmacology Biochemistry and Behavior. en. 46. 3. 543–552. 10.1016/0091-3057(93)90542-2. 8278431. 25509449. 0091-3057.
  7. Josselyn. Sheena A.. Vaccarino. Franco J.. 1995-01-01. Interaction of CCKB receptors with amphetamine in responding for conditioned rewards. Peptides. en. 16. 5. 959–964. 10.1016/0196-9781(95)00066-S. 7479342. 32064336. 0196-9781.
  8. Josselyn. S. A.. Frankland. P. W.. Petrisano. S.. Bush. D. E. A.. Yeomans. J. S.. Vaccarino. F. J.. 1995-01-01. The CCKB antagonist, L-365,260, attenuates fear-potentiated startle. Peptides. en. 16. 7. 1313–1315. 10.1016/0196-9781(95)02013-M. 8545257. 25951941. 0196-9781.
  9. Josselyn. S. A.. Franco. V. P.. Vaccarino. F. J.. 1996-01-01. Devazepide, a CCKA receptor antagonist, impairs the acquisition of conditioned reward and conditioned activity. Psychopharmacology. 123. 2. 131–143. 10.1007/bf02246170. 0033-3158. 8741936. 10061243.
  10. Web site: SC Talks: "How Memories Are Formed", Sheena Josselyn, November 20, 2019. Senior College. en-US. 2020-03-26.
  11. Kida. Satoshi. Josselyn. Sheena A.. de Ortiz. Sandra Peña. Kogan. Jeffrey H.. Chevere. Itzamarie. Masushige. Shoichi. Silva. Alcino J.. 2002-04-01. CREB required for the stability of new and reactivated fear memories. Nature Neuroscience. en. 5. 4. 348–355. 10.1038/nn819. 11889468. 9255921. 1546-1726.
  12. Silva. Alcino J.. Josselyn. Sheena A.. 2002-08-01. The molecules of forgetfulness. Nature. en. 418. 6901. 929–930. 10.1038/418929a. 12198533. 4342684. 1476-4687. free.
  13. Han. Jin-Hee. Yiu. Adelaide P.. Cole. Christina J.. Hsiang. Hwa-Lin. Neve. Rachael L.. Josselyn. Sheena A.. 2008-06-01. Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear. Learning & Memory. en. 15. 6. 443–453. 10.1101/lm.993608. 1072-0502. 18519545. 2414255. free.
  14. Han. Jin-Hee. Kushner. Steven A.. Yiu. Adelaide P.. Hsiang. Hwa-Lin (Liz). Buch. Thorsten. Waisman. Ari. Bontempi. Bruno. Neve. Rachael L.. Frankland. Paul W.. Josselyn. Sheena A.. 2009-03-13. Selective Erasure of a Fear Memory. Science. en. 323. 5920. 1492–1496. 10.1126/science.1164139. 0036-8075. 19286560. 2009Sci...323.1492H. 1257448.
  15. Levy . Adam . Memory, the mystery . Knowable Magazine . 14 January 2021 . 10.1146/knowable-011421-3 . free . 25 March 2022.
  16. Web site: Congratulations to newly elected fellows of the Royal Society of Canada, and to the incoming class of the college of new scientists – Canadian Association for Neuroscience. en-CA. 2020-03-26.
  17. Web site: Daniel H. Efron Research Previous Award Winners. ACNP. en-US. 2020-03-26.
  18. Web site: Sheena Josselyn University of Lethbridge. www.uleth.ca. 2020-03-26.

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