Shearinine Explained

thumb|Shearinines A,D,E,and F

Shearinines A,D,E,and F, are marine fungal isolates with anticancer activity in vitro. They were isolated from a stain of Penicillium janthinellum Biourge. Their potential anticancer activity has been suggested by their induction of apoptosis in HL-60 cells.^[1] Shearinines D, E and G have also been found to block activity on large-conductance calcium-activated potassium channels.^[2]

Notes and References

1. Indole alkaloids produced by a marine fungus isolate of Penicillium janthinellum Biourge . Smetanina OF, etal . J Nat Prod . Jun 2007 . 70 . 6 . 906–9. . 10.1021/np060396d . 17555349.
2. Shearinines D–K, new indole triterpenoids from an endophytic Penicillium sp. (strain HKI0459) with blocking activity on large-conductance calcium-activated potassium channels . Xu, Minjuan. Tetrahedron . Jan 2007 . 63 . 2 . 435–444 . 10.1016/j.tet.2006.10.050. etal.