Sharon R. Browning Explained

Sharon R. Browning
Birth Date:1973
Alma Mater:University of Washington
Thesis Title:Monte Carlo likelihood calculation for identity by descent data
Thesis Url:http://hdl.handle.net/1773/8949
Thesis Year:1999
Doctoral Advisor:Elizabeth A. Thompson

Sharon Ruth Browning is a statistical geneticist at the University of Washington,[1] and a research professor with its Department of Biostatistics.[2] [3] [4] Her research has various implications for the field of biogenetics.

Education and career

Browning has a B.Sc. from the University of Auckland (1995) and earned her Ph.D. in 1999 from the University of Washington.[5] Following her Ph.D., she held positions at Texas A&M University, North Carolina State University, GlaxoSmithKline, and the University of Auckland before moving to the University of Washington in 2010.[6]

Research

Browning is known for her research developing statistical methods for analysis of population genetic data. Her early work established the used of Markov chain modeling to examine association based genome mapping.[7] Her work addresses how to handle missing data in whole-genome association studies.[8] [9] She has also defined the use of group association tests[10] and examined relatedness of individuals based on shared gene content.[11] [12] Browning has also examined the genetic history of the Samoans.[13] [14]

Browning and her research group also study the traces of genetic introgression from archaic humans into modern human DNA. In 2018, they discoveredthat humans in the distant past had mated with Denisovans in at least two separate events, the second of which may have occurred as humans migrated eastward into Asia and Oceania.[15] [16] [17]

Selected publications

Notes and References

  1. News: A Blended Family: Her Mother Was Neanderthal, Her Father Something Else Entirely. Zimmer. Carl. 2018-08-22. The New York Times. 2019-04-05. en-US. 0362-4331.
  2. Web site: Ancient Human Groups Mated With the Mysterious Denisovans at Least Twice. Dvorsky. George. Gizmodo. 15 March 2018 . en-US. 2019-04-05.
  3. Web site: Mysterious Denisovans interbred with modern humans more than once. 16 March 2018. CNN. 2018-03-16.
  4. Web site: Modern humans interbred with Denisovans twice in history. 2018-03-15.
  5. Monte Carlo likelihood calculation for identity by descent data. 1999. Thesis. en-US. Sharon. Browning.
  6. Web site: Browning CV. December 19, 2021.
  7. Browning. Sharon R.. 2006-06-01. Multilocus Association Mapping Using Variable-Length Markov Chains. The American Journal of Human Genetics. English. 78. 6. 903–913. 10.1086/503876. 0002-9297. 1474089. 16685642.
  8. Browning. Sharon R.. Browning. Brian L.. 2007. Rapid and Accurate Haplotype Phasing and Missing-Data Inference for Whole-Genome Association Studies By Use of Localized Haplotype Clustering. The American Journal of Human Genetics. en. 81. 5. 1084–1097. 10.1086/521987. 2265661. 17924348.
  9. Browning. Sharon R.. 2008. Missing data imputation and haplotype phase inference for genome-wide association studies. Human Genetics. en. 124. 5. 439–450. 10.1007/s00439-008-0568-7. 0340-6717. 2731769. 18850115.
  10. Madsen. Bo Eskerod. Browning. Sharon R.. 2009-02-13. Schork. Nicholas J.. A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic. PLOS Genetics. en. 5. 2. e1000384. 10.1371/journal.pgen.1000384. 1553-7404. 2633048. 19214210 . free .
  11. Browning. Sharon R.. Browning. Brian L.. 2012-12-15. Identity by Descent Between Distant Relatives: Detection and Applications. Annual Review of Genetics. en. 46. 1. 617–633. 10.1146/annurev-genet-110711-155534. 22994355. 0066-4197.
  12. Browning. Sharon R.. Browning. Brian L.. 2010. High-Resolution Detection of Identity by Descent in Unrelated Individuals. The American Journal of Human Genetics. en. 86. 4. 526–539. 10.1016/j.ajhg.2010.02.021. 2850444. 20303063.
  13. Harris. Daniel N.. Kessler. Michael D.. Shetty. Amol C.. Weeks. Daniel E.. Minster. Ryan L.. Browning. Sharon. Cochrane. Ethan E.. Deka. Ranjan. Hawley. Nicola L.. Reupena. Muagututi‘a Sefuiva. Naseri. Take. 2020-04-28. Evolutionary history of modern Samoans. Proceedings of the National Academy of Sciences. en. 117. 17. 9458–9465. 10.1073/pnas.1913157117. 0027-8424. 7196816. 32291332. 2020PNAS..117.9458H . free.
  14. Web site: Researchers use 21st century genomics to estimate Samoan population dynamics over 3,000 years. 2021-12-23. Brown University. en.
  15. Web site: 2019-04-11. Multiple lines of mysterious ancient humans interbred with us. 2021-12-23. Science. en.
  16. News: Guarino. Ben. March 15, 2018. Humans bred with this mysterious species more than once, new study shows. en-US. Washington Post. 2021-12-23. 0190-8286.
  17. Browning. Sharon R.. Browning. Brian L.. Zhou. Ying. Tucci. Serena. Akey. Joshua M.. 2018. Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture. Cell. en. 173. 1. 53–61.e9. 10.1016/j.cell.2018.02.031. 5866234. 29551270.

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