Shane Crotty Explained

Shane Crotty
Birth Name:Shane Patrick Crotty
Birth Date:26 January 1974
Workplaces:La Jolla Institute for Immunology
Thesis Title:Polio Is (Still) Not Dead: Vaccine Vectors, Antiviral Drugs, Pathogenesis, and Unexpected Mutants
Thesis Url:https://search.library.ucsf.edu/permalink/01UCS_SAF/88i771/alma991000019879706536
Thesis Year:2001
Doctoral Advisor:Raul Andino
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Shane Patrick Crotty (born 26 January 1974) is a professor of immunology in the Center for Infectious Disease and Vaccine Research at La Jolla Institute for Immunology.[1]

Education and academic posts

Crotty completed B.S. degrees in Biology and Writing from Massachusetts Institute of Technology in 1996.[1] He then completed his Ph.D. in 2001 at the University of California, San Francisco with Raul Andino.[2] [1]

Crotty went on to a postdoctoral fellowship from 2001 to 2003 with Rafi Ahmed at Emory University Vaccine Center studying immunity to viruses.[1] He joined the La Jolla Institute for Immunology (LJI) in 2003, as well as the department of medicine of University of California, San Diego, in 2004 as an adjunct assistant professor. He became an associate member with tenure at LJI in 2009,[3] and then a tenured professor.

Research

Crotty's research has focused on immune responses to viral infections, in particular those driven by vaccines. His lab has done major work on the regulation and proliferation of follicular helper T cells, as well as immunological protection from HIV infection and HIV vaccine delivery strategy.[4] [5] In close collaboration with Alessandro Sette, Crotty published the first detailed analysis[6] of the human immune response to SARS-CoV-2, the virus that causes COVID-19, and later confirmed[7] that the adaptive immune response is lasting.

In 2020, Crotty joined the LJI Coronavirus Taskforce to study immune system responses with an aim of informing vaccines and therapies against the novel coronavirus, SARS-CoV-2. His lab studies the adaptive immune response against SARS-CoV-2.[8] In May 2020, his lab co-published the first detailed analysis of how the immune system responds to SARS-CoV-2, with LJI Professor Alessandro Sette.[9] [10] This research suggested that the human body may be capable of long-term immunity to SARS-CoV-2 following infection or vaccine administration.[11] Crotty has since published research showing that "uncoordinated" immune cell responses are related to COVID-19 case severity.[10] His lab has also collaborated with Sette to show that T cells that react to common cold coronaviruses can also recognize SARS-CoV-2.[12] Crotty has warned that this T-cell immunity does not equal protection against the virus.[13]

Major publications

Other publications

Crotty is also the author of a biography of David Baltimore entitled Ahead of the Curve.[14] [15] He is the co-editor with Rafi Ahmed of Immune Memory and Vaccines: Great Debates.[16]

Notes and References

  1. News: Crotty Lab - Lab Members . 11 July 2019 . La Jolla Institute for Immunology . La Jolla Institute.
  2. Web site: Shane Crotty . 11 July 2019 . Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery.
  3. Web site: Biographical Sketch. Shane . Crotty .
  4. Web site: Crotty Lab . La Jolla Institute for Immunology .
  5. Web site: New HIV vaccine strategy 'pumps' the immune system. May 9, 2019 . Science Daily .
  6. Grifoni. Alba. Weiskopf. Daniela. Ramirez. Sydney I.. Mateus. Jose. Dan. Jennifer M.. Moderbacher. Carolyn Rydyznski. Rawlings. Stephen A.. Sutherland. Aaron. Premkumar. Lakshmanane. Jadi. Ramesh S.. Marrama. Daniel. June 2020. Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Cell. 181. 7. 1489–1501.e15. 10.1016/j.cell.2020.05.015. 0092-8674. 7237901. 32473127.
  7. Dan. Jennifer M.. Mateus. Jose. Kato. Yu. Hastie. Kathryn M.. Yu. Esther Dawen. Faliti. Caterina E.. Grifoni. Alba. Ramirez. Sydney I.. Haupt. Sonya. Frazier. April. Nakao. Catherine. 2021-01-06. Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection. Science. 371 . 6529 . en. eabf4063. 10.1126/science.abf4063. 33408181 . 7919858 . 0036-8075. free.
  8. Web site: Crotty Lab. 2021-04-23. La Jolla Institute for Immunology. en-US.
  9. Web site: First detailed analysis of immune response to SARS-CoV-2 bodes well for COVID-19 vaccine development. 2021-04-23. La Jolla Institute for Immunology. en-US.
  10. Grifoni. Alba. Weiskopf. Daniela. Ramirez. Sydney I.. Mateus. Jose. Dan. Jennifer M.. Moderbacher. Carolyn Rydyznski. Rawlings. Stephen A.. Sutherland. Aaron. Premkumar. Lakshmanane. Jadi. Ramesh S.. Marrama. Daniel. 2020-06-25. Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals. Cell. English. 181. 7. 1489–1501.e15. 10.1016/j.cell.2020.05.015. 0092-8674. 32473127. 7237901.
  11. Web site: Leslie. Mitch. 2020-05-14. T cells found in COVID-19 patients 'bode well' for long-term immunity. 2021-04-23. Science AAAS. en.
  12. Mateus. Jose. Grifoni. Alba. Tarke. Alison. Sidney. John. Ramirez. Sydney I.. Dan. Jennifer M.. Burger. Zoe C.. Rawlings. Stephen A.. Smith. Davey M.. Phillips. Elizabeth. Mallal. Simon. 2020-10-02. Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. en. 370. 6512. 89–94. 10.1126/science.abd3871. 7574914. 0036-8075. 32753554. 2020Sci...370...89M . free.
  13. Sette. Alessandro. Crotty. Shane. August 2020. Pre-existing immunity to SARS-CoV-2: the knowns and unknowns. Nature Reviews Immunology. en. 20. 8. 457–458. 10.1038/s41577-020-0389-z . 32636479 . 7339790. 1474-1741. free.
  14. Ahead of the Curve: David Baltimore's Life in Science . Didier Trono . Didier Trono . Nature Medicine . July 2001 . 7 . 7 . 767 . 10.1038/89868. 41609105 . free .
  15. Ahead of the Curve: David Baltimore's Life in Science (review) . Barbara J. Culliton. Bulletin of the History of Medicine . 77. 2. 2003. 474–475 . 10.1353/bhm.2003.0056 . 71233143 .
  16. Book: Shane Crotty. Ahmed, Rafi. Immune Memory and Vaccines: Great Debates. 2018. Cold Spring Harbor Laboratory Press. 978-1-62182-154-0.

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