Shana O. Kelley Explained

Shana O. Kelley
Workplaces:Boston College
University of Toronto
Northwestern University
Chan Zuckerberg Biohub
Spouse:Edward H. Sargent
Thesis Title:Electron transfer through the DNA double helix: spectroscopic and electrochemical studies
Thesis Url:https://thesis.library.caltech.edu/4085/
Thesis Year:1999
Doctoral Advisor:Jacqueline Barton
Academic Advisors:Paul Schimmel

Shana O. Kelley is a scientist and Neena B. Schwartz Professor of Chemistry and Biomedical Engineering at Northwestern University. She is affiliated with Northwestern's International Institute for Nanotechnology[1] and was previously part of the University of Toronto's Faculty of Pharmacy and Faculty of Medicine. Kelley's research includes the development of new technologies for clinical diagnostics and drug delivery.[2] In 2023, she was chosen as president of Chicago's new Chan Zuckerberg Biohub.[3]

Education and training

Kelley received her BS from Seton Hall University in 1994. She pursued graduate studies in chemistry at the California Institute of Technology, where she worked with Jacqueline Barton. She graduated with her PhD in 1999 with a dissertation entitled Electron Transfer through the DNA Double Helix: Spectroscopic and Electrochemical Studies.[4]

From 1999 to 2000, Kelley was a NIH Postdoctoral Fellow at the Scripps Research Institute, where she worked with Paul Schimmel.[5] [6]

Career

Kelley began her independent research career as an Assistant Professor in the Chemistry Department at Boston College in 2000. In 2006, she was promoted directly to the rank of Full Professor and in 2007, she joined the Leslie Dan Faculty of Pharmacy at the University of Toronto.[7] In August 2021, she joined Northwestern University's Departments of Chemistry and Biomedical Engineering as a named professor.[8] [9] It was announced in March 2023 that she would head the new Chan Zuckerberg Biohub in Chicago, which will be a collaboration between Northwestern, University of Chicago, and University of Illinois at Urbana-Champaign.[10]

Kelley founded a university spin-off company named GeneOhm Sciences with her graduate advisor Jacqueline Barton. GeneOhm Sciences was based on a discovery that Kelley made during her graduate studies, where she developed a method to detect mutations in DNA by modifying the DNA strands and measuring their differing conductivity.[11] [12] [13] GeneOhm Sciences used Kelley's discovery to create a diagnostic test for antibiotic-resistant MRSA bacteria.[14] GeneOhm was acquired by Becton Dickinson in early 2006.[15] Kelley also founded the molecular diagnostics company Xagenic Inc.[16] In April 2023, she started a new company, CTRL Therapeutics, which aims to improve existing cell therapy in cancer treatment by focusing on the CTRL gene.[17]

Awards

Personal life

Kelley is married to fellow University of Toronto Professor Ted Sargent.[34] [35] They met at a nanotechnology conference at UC Irvine, and have two children together.[36]

External links

Notes and References

  1. Web site: Internationally renowned researchers Shana Kelley and Ted Sargent join Northwestern – Weinberg College News. August 24, 2021. news.weinberg.northwestern.edu.
  2. Web site: Shana O. Kelley. University of Toronto.
  3. Web site: Chao . Julie . 2023-05-15 . High Risk, High Reward: Shana Kelley on Building a New Biohub . 2023-06-22 . CZ Biohub . en-US.
  4. Electron transfer through the DNA double helix: spectroscopic and electrochemical studies. Kelley. Shana O. . 1999. thesis.library.caltech.edu. 10.7907/HZ7H-AD50. November 14, 2018. phd.
  5. Kelley. Shana O.. Steinberg. Sergey V.. Schimmel. Paul. 2000. Functional defects of pathogenic human mitochondrial tRNAs related to structural fragility. Nature Structural Biology. en. 7. 10. 862–865. 10.1038/79612. 11017193. 11745118. 1545-9985.
  6. Kelley. Shana O.. Steinberg. Sergey V.. Schimmel. Paul. April 6, 2001. Fragile T-stem in Disease-associated Human Mitochondrial tRNA Sensitizes Structure to Local and Distant Mutations *. Journal of Biological Chemistry. English. 276. 14. 10607–10611. 10.1074/jbc.M008320200. 0021-9258. 11110797. free.
  7. Web site: Shana Kelley – Division of the Vice-President & Provost. July 10, 2021. en.
  8. Web site: Internationally renowned researchers Shana Kelley and Ted Sargent join Northwestern. 2021-08-23. Weinberg College of Arts & Sciences, Northwestern University. 2023-04-24.
  9. Web site: Fall 2022 ACS Meeting Doolittle Award Awarded to Prof. Shana Olwyn Kelley. 2022-10-18. PMSE. 2023-04-24.
  10. Web site: Exclusive: Mark Zuckerberg And Priscilla Chan On Their New 'Biohub' In Chicago And How They Plan To Spend Billions To Help Others Cure Or Manage Disease. 2023-03-02. Dolan. Kerry A.. Forbes. 2023-04-24.
  11. Kelley. Shana O.. Jackson. Nicole M.. Hill. Michael G.. Barton. Jacqueline K.. 1999. Long-Range Electron Transfer through DNA Films. Angewandte Chemie International Edition. en. 38. 7. 941–945. 10.1002/(SICI)1521-3773(19990401)38:7<941::AID-ANIE941>3.0.CO;2-7. 29711858. 1521-3773.
  12. Kelley. S.. December 15, 1999. Single-base mismatch detection based on charge transduction through DNA. Nucleic Acids Research. 27. 24. 4830–4837. 10.1093/nar/27.24.4830. 1362-4962. 148785. 10572185.
  13. Web site: Patent No. US 6,221,586 B1.
  14. Web site: March 25, 2019. Shana Kelley on founding, developing life science startups. July 10, 2021. The Varsity. en-US.
  15. News: BD Acquires GeneOhm Sciences for $230M in Bid to Bolster Infectious-Disease Play. en. GenomeWeb. November 14, 2018.
  16. News: Shana Kelley: A quicker way to diagnose disease. November 14, 2018.
  17. Web site: Northwestern researcher spins out tumor-fighting therapy company. Chicago Business. 2023-04-11. Asplund. Jon. 2023-04-24.
  18. Web site: 2008 – Canada's Top 40 Under 40.
  19. Web site: Innovator Under 35: Shana Kelley, 34. November 14, 2018. MIT Technology Review. en-us.
  20. Web site: Government of Canada. Natural Sciences and Engineering Research Council of Canada. June 28, 2016. NSERC – E.W.R. Steacie – Shana Kelley. July 10, 2021. Natural Sciences and Engineering Research Council of Canada (NSERC).
  21. Web site: Nanotechnology Now – Press Release: 2011 Steacie Prize awarded for nanotechnology-enabled disease diagnosis: Pharmacy's Shana Kelley third consecutive U of T professor to win prestigious science and engineering award. July 10, 2021. www.nanotech-now.com. en.
  22. Web site: September 24, 2020. New Tools to Rapidly Diagnose Infections and Detect Antibiotic-Resistant Bacteria – Society for Laboratory Automation and Screening. July 10, 2021. https://web.archive.org/web/20200924133244/https://www.slas.org/eln/new-tools-to-rapidly-diagnose-infections-and-detect-antibiotic-resistant-bacteria/. September 24, 2020.
  23. Web site: Government of Canada. Natural Sciences and Engineering Research Council of Canada. June 28, 2016. NSERC – Brockhouse – Winners. July 10, 2021. Natural Sciences and Engineering Research Council of Canada (NSERC).
  24. Web site: Shana Kelley Shana O. Kelley, Ph.D. To be Inducted into Medical and Biological Engineering Elite – AIMBE. July 10, 2021. en.
  25. Web site: Wang. Linda. May 15, 2017. Inorganic award to Shana Kelley. July 10, 2021. cen.acs.org.
  26. Web site: Somorjai Award. July 10, 2021. miller.berkeley.edu.
  27. Web site: Rowland Institute Visiting Distinguished Scholar – Professor Shana Kelley. July 10, 2021. www2.rowland.harvard.edu. en.
  28. Web site: 2020 AFPC Award Winners afpc. July 10, 2021. www.afpc.info.
  29. Web site: PRESS RELEASE THE RSC PRESENTS THE CLASS OF 2021 The Royal Society of Canada . April 3, 2022 . rsc-src.ca. September 7, 2021 .
  30. Web site: Ontario Newsroom. July 10, 2021. news.ontario.ca.
  31. Web site: Shana Kelley Named Guggenheim Fellow . . April 12, 2022 . April 12, 2022.
  32. Web site: Meet Our 2022 Fellows . John Simon Guggenheim Memorial Foundation . April 12, 2022.
  33. Web site: New Members Elected in 2023. American Academy of Arts and Sciences. 2023-04-24.
  34. Web site: Sargent wins Steacie Prize for outstanding young Canadian researcher. June 2, 2021. University of Toronto News. en.
  35. News: July 30, 2006. Shana Kelley, Ted Sargent. en-US. The New York Times. June 2, 2021. 0362-4331.
  36. Web site: Nayyar. Anjum. February 13, 2012. Campus couple balances challenges of work, home. June 4, 2021. University of Toronto News. en.

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