| Official Name: | Shakertowne, Missouri |
| Settlement Type: | Census-designated place |
| Pushpin Map: | Missouri#USA |
| Pushpin Label: | Shakertowne |
| Coordinates: | 37.6939°N -89.8675°W |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Missouri |
| Subdivision Type2: | County |
| Subdivision Name2: | Perry |
| Subdivision Type3: | Townships |
| Subdivision Name3: | Central Cinque Hommes |
| Area Footnotes: | [1] |
| Area Total Sq Mi: | 1.32 |
| Area Land Sq Mi: | 1.32 |
| Area Water Sq Mi: | 0.00 |
| Area Total Km2: | 3.42 |
| Area Land Km2: | 3.42 |
| Area Water Km2: | 0.00 |
| Population As Of: | 2020 |
| Population Density Km2: | 182.76 |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 600 |
| Postal Code Type: | ZIP Code |
| Postal Code: | 63775 (Perryville) |
| Area Code: | 573 |
| Blank Name: | FIPS code |
| Blank Info: | 29-66935 |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 2806418 |
| Population Total: | 625 |
| Unit Pref: | Imperial |
| Population Density Sq Mi: | 473.48 |
Shakertowne is an unincorporated community and census-designated place (CDP) in Perry County, Missouri, United States. It is in the central part of the county and is bordered to the north by Perryville, the county seat. Interstate 55 forms the western edge of the CDP; the closest access is from Exit 129 (Missouri Route 51) in Perryville. Via I-55 St. Louis is to the north and Cape Girardeau is to the south.
Shakertowne was first listed as a CDP prior to the 2020 census.