Set domain containing 1b explained
SET domain containing 1B is a protein that in humans is encoded by the SETD1B gene.[1]
Function
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008].
Further reading
- Lee JH, Skalnik DG . Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation . PLOS ONE . 7 . 8 . e42965 . 2012 . 22927943 . 3424240 . 10.1371/journal.pone.0042965 . 2012PLoSO...742965L . free .
- Choi YJ, Oh HR, Choi MR, Gwak M, An CH, Chung YJ, Yoo NJ, Lee SH . Frameshift mutation of a histone methylation-related gene SETD1B and its regional heterogeneity in gastric and colorectal cancers with high microsatellite instability . Hum. Pathol. . 45 . 8 . 1674–81 . 2014 . 24925220 . 10.1016/j.humpath.2014.04.013 .
- Labonne JD, Lee KH, Iwase S, Kong IK, Diamond MP, Layman LC, Kim CH, Kim HG . An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability . Hum. Genet. . 135 . 7 . 757–71 . 2016 . 27106595 . 10.1007/s00439-016-1668-4 . 3760488 .
- Kranz. Andrea. Anastassiadis. Konstantinos. The role of SETD1A and SETD1B in development and disease. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1863. 8. 2020. 194578. 1874-9399. 10.1016/j.bbagrm.2020.194578 . 32389824. 218585660.
- Brici . David. Zhang. Qinyu . Reinhardt . Susanne. Dahl. Andreas. Hartmann . Hella. Schmidt . Kerstin. Goveas. Neha. Huang. Jiahao . Gahurova. Lenka. Kelsey. Gavin . Anastassiadis. Konstantinos. Stewart. A. Francis. Kranz. Andrea. The histone 3 lysine 4 methyltransferase Setd1b is a maternal effect gene required for the oogenic gene expression program. Development. 2017. 144. 14. 2606–2617. 1477-9129. 10.1242/dev.143347. 28619824. free.
Notes and References
- Web site: Entrez Gene: SET domain containing 1B. 2018-01-13.
