| Honorific-Prefix: | Most Reverend |
| Sestilio Mazuca | |
| Bishop of Alessano | |
| Church: | Catholic Church |
| Diocese: | Diocese of Alessano |
| Term: | 1592–1594 |
| Predecessor: | Settimio Borsari |
| Successor: | Orazio Rapari |
Sestilio Mazuca or Sextilius Mazuca or Sestilio Massuca or Sextilius Massuca was a Roman Catholic prelate who served as Bishop of Alessano (1592–1594).[1] [2]
On 19 June 1592, Sestilio Mazuca was appointed during the papacy of Pope Clement VIII as Bishop of Alessano. He served as Bishop of Alessano until his resignation in 1594.