Serrate RNA effector molecule homolog explained

Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a protein that in humans is encoded by the SRRT gene.^[1]

The SRRT gene product plays a role in RNA-mediated gene silencing (RNAi) by miRNAs. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural stem cell self-renewal, by directly binding to the SOX2 promoter and positively regulating its transcription. It enables the binding activity of the mRNA cap binding complex and the adaptor activity of certain protein molecules. It can be found in the nucleoplasm and is part of the ribonucleoprotein complex. It is involved in cell cycle progression around the S phase.^[2]

It does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Diseases associated with SRRT include spondylocostal dysostosis and cerebral arteriopathy.

Further reading

• Rossman TG, Wang Z . Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis. . Carcinogenesis . 20 . 2 . 311–6 . 1999 . 10069470 . 10.1093/carcin/20.2.311 . free .
• Wilson MD, Riemer C, Martindale DW, etal . Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. . Nucleic Acids Res. . 29 . 6 . 1352–65 . 2001 . 11239002 . 10.1093/nar/29.6.1352 . 29746 .
• Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology. . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 2882961 . 10.1126/science.1083423 . 2003Sci...300..767S .
• Di Y, Li J, Zhang Y, etal . HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins. . J. Biochem. . 133 . 6 . 713–8 . 2004 . 12869526 . 10.1093/jb/mvg091 .
• Obuse C, Yang H, Nozaki N, etal . Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. . Genes Cells . 9 . 2 . 105–20 . 2004 . 15009096 . 10.1111/j.1365-2443.2004.00705.x . 21813024 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .
• Ballif BA, Villén J, Beausoleil SA, etal . Phosphoproteomic analysis of the developing mouse brain. . Mol. Cell. Proteomics . 3 . 11 . 1093–101 . 2005 . 15345747 . 10.1074/mcp.M400085-MCP200 . free .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization. . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Szafranski K, Schindler S, Taudien S, etal . Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. . Genome Biology. 8 . 8 . R154 . 2007. 17672918 . 10.1186/gb-2007-8-8-r154 . 2374985 . free .

Notes and References

1. Web site: Entrez Gene: ARS2 ARS2 protein.
2. Web site: SRRT Gene . GeneCards . 31 January 2023.