| Serpentine | |
| Map Size: | 280 |
| Pushpin Map: | Australia Tasmania |
| Pushpin Map Size: | 280 |
| Pushpin Map Caption: | Location of the Serpentine River mouth in Tasmania |
| Subdivision Type1: | Country |
| Subdivision Name1: | Australia |
| Subdivision Type2: | State |
| Subdivision Name2: | Tasmania |
| Subdivision Type3: | Region |
| Subdivision Name3: | South-west, Western |
| Length: | 26km (16miles) |
| Source1: | Wilmont Range |
| Source1 Location: | Lake Pedder |
| Source1 Coordinates: | -42.9333°N 153°W |
| Source1 Elevation: | 313m (1,027feet) |
| Mouth: | Gordon River |
| Mouth Location: | Gordon Splits |
| Mouth Coordinates: | -42.7481°N 145.9608°W |
| Mouth Elevation: | 122m (400feet) |
| River System: | Gordon-Franklin catchment |
| Custom Label: | Reservoir |
| Custom Data: | Lake Pedder |
| Extra: | [1] |
The Serpentine River is a major perennial river located in the south-west and western regions of Tasmania, Australia.
The Serpentine River is almost entirely inundated by the current Lake Pedder. Before its flooding the river rose at the northwestern corner of the original Lake Pedder and drained the eastern slopes of the Frankland and Wilmot ranges. It flows generally north by northwest, joined by one minor tributary. The river is impounded by the Serpentine Dam, one of three dams that create Lake Pedder, and then flows towards the Gordon Splits where it reaches its confluence with the Gordon River.[2]