| Sernio | |
| Official Name: | Comune di Sernio |
| Coordinates: | 46.2167°N 22°W |
| Region: | Lombardy |
| Province: | Sondrio (SO) |
| Mayor: | Piero Patroni |
| Area Total Km2: | 9.6 |
| Population Footnotes: | [1] |
| Population Total: | 470 |
| Population As Of: | Dec. 2004 |
| Elevation M: | 632 |
| Postal Code: | 23030 |
| Area Code: | 0342 |
Sernio is a comune (municipality) in the Province of Sondrio in the Italian region Lombardy, located about 120km (80miles) northeast of Milan and about 25km (16miles) east of Sondrio.