| Sermizelles | |
| Commune Status: | Commune |
| Coordinates: | 47.5369°N 3.7939°W |
| Insee: | 89392 |
| Postal Code: | 89200 |
| Arrondissement: | Avallon |
| Canton: | Avallon |
| Mayor: | Franck Moinard[1] |
| Term: | 2020 - 2026 |
| Elevation Min M: | 127 |
| Elevation Max M: | 265 |
| Area Km2: | 7.01 |
Sermizelles (in French pronounced as /sɛʁmizɛl/) is a commune in the Yonne department in Bourgogne-Franche-Comté in north-central France.
Located close by is the Château de Domecy-sur-le-Vault.