| Sermesse | |
| Commune Status: | Commune |
| Insee: | 71517 |
| Postal Code: | 71350 |
| Arrondissement: | Chalon-sur-Saône |
| Canton: | Gergy |
| Coordinates: | 46.9011°N 5.0883°W |
| Elevation M: | 194 |
| Elevation Min M: | 173 |
| Elevation Max M: | 197 |
| Area Km2: | 8.36 |
Sermesse (in French pronounced as /sɛʁmɛs/) is a commune in the Saône-et-Loire department in the region of Bourgogne-Franche-Comté in eastern France.