| Competition: | Serie A |
| Season: | –89 |
| Dates: | 9 October 1988 – 25 June 1989 |
| Winners: | Internazionale 13th title |
| Continentalcup1: | European Cup |
| Continentalcup1 Qualifiers: | Internazionale Milan |
| Continentalcup3: | UEFA Cup |
| Continentalcup3 Qualifiers: | Napoli Juventus Atalanta Fiorentina |
| Continentalcup2: | Cup Winners' Cup |
| Continentalcup2 Qualifiers: | Sampdoria |
| League Topscorer: | Aldo Serena (22 goals) |
| Longest Wins: | 26 matches Inter Milan |
| Longest Unbeaten: | 21 matches Milan |
| Longest Winless: | 5 wins Lazio |
| Relegated: | Torino Pescara Pisa Calcio |
| Matches: | 306 |
| Total Goals: | 645 |
| Prevseason: | 1987–88 |
| Nextseason: | 1989–90 |
The 1988–89 Serie A was won by Internazionale, who won the title comfortably by an 11-point margin over runners-up Napoli. Milan's triumph in the European Cup meant Italy would be entering two teams – both the two giant Milan sides – into the European Cup for the 1989–90 season. Relegated to Serie B were Torino, Pescara, Pisa and Como.
Bologna, Lecce, Lazio and Atalanta had been promoted from Serie B.
Following the expansion of the league, a fourth relegation was added.
Fiorentina qualified for 1989–90 UEFA Cup.
