| Competition: | Serie A |
| Season: | 1948–49 |
| Winners: | Torino 6th title |
| Relegated: | Modena Livorno |
| League Topscorer: | István Nyers (26 goals) |
| Matches: | 380 |
| Total Goals: | 1110 |
| Prevseason: | 1947–48 |
| Nextseason: | 1949–50 |
Torino were declared 1948–49 Serie A champions on 6 May 1949, after the Superga tragedy, an air disaster that killed the entire Torino squad. At the time of the declaration, Torino led the runner-up Internazionale by four points with four matches remaining.[1] Their remaining four matches were played by their reserve team, and they finished the league five points ahead of the runner up.
Novara for Northern Italy, Padova for Central Italy and Palermo for Southern Italy had been promoted from Serie B.
Following the restoration of ordinary Serie B championship, the FIGC decided to come back to two relegations only from Serie A.
| Rank | Player | Club | Goals |
|---|---|---|---|
| 1 | István Nyers | Internazionale | 26 |
| 2 |  Amedeo Amadei | Internazionale | 22 |
| 3 | István Mike Mayer | Bologna | 20 |
| 4 | Carlo Stradella | Livorno | 19 |
| 5 | Riccardo Carapellese | Milan | 17 |
| 6 | Valentino Mazzola | Torino | 16 |
 Gunnar Nordahl | Milan | ||
| 8 | Giuseppe Baldini | Sampdoria | 15 |
| Renato Gei | Sampdoria | ||
| Giampiero Boniperti | Juventus | ||
| John Hansen | Juventus | ||
| Bruno Ispiro | Triestina | ||
| Ugo Conti | Lucchese | ||
| 14 | Silvio Piola | Novara | 14 |
| Adriano Bassetto | Sampdoria |