| Competition: | Serie A |
| Season: | 1941–42 |
| Size: | 280px |
| Winners: | Roma 1st title |
| Relegated: | Napoli Modena |
| League Topscorer: | Aldo Boffi (22 goals) |
| Matches: | 240 |
| Total Goals: | 687 |
| Prevseason: | 1940–41 |
| Nextseason: | 1942–43 |
The 1941–42 Serie A season was won by Roma.
Liguria and Modena had been promoted from Serie B.
| Rank | Player | Club | Goals | |
|---|---|---|---|---|
| 1 | Milano | 22 | ||
| 2 |  Amedeo Amadei | Roma | 18 | |
| Renato Gei | Fiorentina | |||
| Silvio Piola | Lazio | |||
| 5 | Genova 1893 | 17 | ||
| 6 | Guglielmo Gabetto | Juventus | 16 | |
| 7 |  Riza Lushta | Juventus | 15 | |
| 8 |  Silvestro Pisa | Lazio | 14 | |
| Bologna | ||||
| Romeo Menti | Torino | |||
| 11 | Francesco Pernigo | Venezia | 12 |