| Serhiy Symonenko | |
| Fullname: | Serhiy Yuriyovych Symonenko |
| Birth Date: | 12 June 1981 |
| Birth Place: | Kupiansk, Ukrainian SSR, Soviet Union |
| Height: | 1.85 m |
| Position: | Defender |
| Youthclubs1: | RVUFK Kyiv |
| Years1: | 1999–2001 |
| Clubs1: | Torpedo Moscow |
| Caps1: | 5 |
| Goals1: | 1 |
| Years2: | 1999–2000 |
| Clubs2: | → Torpedo-d Moscow |
| Caps2: | 49 |
| Goals2: | 7 |
| Years3: | 2002 |
| Caps3: | 5 |
| Goals3: | 0 |
| Years4: | 2003–2007 |
| Caps4: | 92 |
| Goals4: | 4 |
| Years5: | 2003 |
| Caps5: | 3 |
| Goals5: | 0 |
| Years6: | 2007–2013 |
| Clubs6: | Arsenal Kyiv |
| Caps6: | 123 |
| Goals6: | 7 |
| Years7: | 2013 |
| Clubs7: | PFC Sevastopol |
| Caps7: | 19 |
| Goals7: | 1 |
| Years8: | 2014 |
| Clubs8: | Bunyodkor |
| Caps8: | 5 |
| Goals8: | 0 |
| Nationalyears1: | 2004 |
| Nationalteam1: | Ukraine |
| Nationalcaps1: | 2 |
| Nationalgoals1: | 0 |
Serhiy Yuriyovych Symonenko (Ukrainian: Сергій Юрійович Симоненко|translit=Serhii Yuriiovych Symonenko; born 12 June 1981) is a Ukrainian retired football defender.
Symonenko started his career in Russia with Torpedo Moscow and then Alania Vladikavkaz before joining Chornomorets Odesa in 2002. After making over 100 appearances in all competitions for Chornomorets he joined Arsenal Kyiv for the start of the 2007–08 season.
In 2004, he played for the Ukraine national team. Symonenko made his debut for Ukraine on 18 February 2004 in an away draw with Libya (1:1). He was replaced on 62nd minute by Vyacheslav Checher.