| Official Name: | Sereno, Missouri |
| Settlement Type: | unincorporated community |
| Mapsize: | 250x200px |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Missouri |
| Subdivision Type2: | County |
| Subdivision Name2: | Perry |
| Subdivision Type3: | Township |
| Subdivision Name3: | Bois Brule |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Ft: | 620 |
| Coordinates: | 37.7978°N -89.8511°W |
| Postal Code Type: | ZIP code |
| Postal Code: | 63775 |
| Area Code: | 573 |
| Blank Name: | FIPS code |
| Blank Info: | 29-66746 [1] |
| Blank1 Name: | GNIS feature ID |
| Blank1 Info: | 726210 |
Sereno is an unincorporated community located in Bois Brule Township in Perry County, Missouri, United States. Sereno is located approximately five miles northeast of Perryville.
The early settlers of Sereno named the community Serena, meaning “a clean, respectable place”. However, when establishing a post office they discovered a place by that name already existed in Missouri, so the name was changed to Sereno.[2]
In 1884, Thomas Moore gave a small tract of his land along Chester Road to William Mattingly for the purpose of building a general store, which was soon followed by a grist mill.[3] A post office operated from 1888 to 1905.[4] The predominantly Catholic town established Our Lady of Victory Catholic parish in 1908.[5]