| Honorific Prefix: | Saint |
| Serena of Rome | |
| Birth Date: | Mid-third century |
| Death Date: | Late-third century |
| Feast Day: | August 16 |
| Venerated In: | Roman Catholic Church |
| Titles: | martyr |
| Beatified Date: | Pre-Congregation |
| Beatified Place: | Roman Empire |
Serena of Rome is a legendary third-century martyr and saint listed in the Martyrologium Romanum. She is listed as the wife of Diocletian, however that claim is unproven and she has been removed from the calendar of saints.
The Martyrologium Romanum states that her feast day is on August 16 and that she was the wife of Diocletian.
Tradition has it that Serena was Diocletian's first wife, before he reached his highest office. A convinced and conscious Christian, when her husband learned of her faith, he repudiated her, perhaps fearing that the presence of a Christian at his side would jeopardize his political career. This may have led to her martyrdom.[1]
However, Serena's existence is considered doubtful. In De mortibus persecutorum, Lactantius states that Prisca and Valeria were the wife and daughter of Diocletian.[1]
The Monks of Ramsgate wrote in their Book of Saints (1921),
According to tradition about Saints Marcellus and Susanna, Serena defended the Christians against the persecutions under her husband. She was cast out and suffered martyrdom.
In the legend of Cyriacus, he is credited with exorcizing demons from two girls, one of whom was Artemisia (or Artemia), the daughter of Diocletian, which resulted in both Artemisia and her mother Serena converting to Christianity.
According some sources, Serena did not die a martyr, but instead spent her days in exile in Magliano Sabina, in the Italian region of Lazio. She is the patron saint of Foglia (Magliano Sabina) and the in is dedicated to her.[1]
She is not mentioned in the current martyrology due to her legendary nature.[2]