Serdar Bulun Explained

Serdar Bulun
Birth Place:Malatya, Turkey
Website:http://www.feinberg.northwestern.edu/sites/obgyn/research/labs/bulun/index.html

Serdar Bulun is a gynecologist, with a special interest in the common gynecologic diseases, endometriosis and uterine fibroids.[1] [2] [3]

Biography

Bulun was born in Malatya, Turkey in 1959 and moved to Istanbul to attend Robert College and thereafter Istanbul University School of Medicine (Çapa Tıp Fakültesi). He completed his residency in obstetrics and gynecology at the University at Buffalo in New York and pursued a sub-specialty fellowship in reproductive endocrinology-infertility at the University of Texas Southwestern Medical Center at Dallas. Starting from 2003, he established a comprehensive women’s health research program at Northwestern, and recruited and supported numerous faculty who focus on steroid hormone-related pathology of uterine, breast and ovarian disorders.[4] Throughout his career, Dr. Bulun has been awarded over $70 million of research funding in endometriosis, uterine fibroids and breast cancer.[5] [6] [7] [8] [9] [10] [11]

Academic career

Bulun discovered the epigenetic basis of endometriosis leading to progesterone resistance in this disease, and introduced aromatase inhibitors as a novel class of drugs to treat it.[12] His team isolated tumor stem cells from uterine fibroids and targeted these to treat this disease. His team discovered the first set of gain-of-function mutations affecting the aromatase gene leading to breast development and estrogen excess in prepubertal humans and contributed to the genetics and systems biology aspects of hormone-responsive disorders of the breast, including cancer.

Bulun is the editor-in-chief of Seminars in Reproductive Medicine.[13] He has been elected to the National Academy of Medicine (formerly known as the Institute of Medicine), the Association of American Physicians and the American Society for Clinical Investigation.[14] [15] [16] He served as the 2015 president for the Society for Reproductive Investigation.[17] He has received the National Institutes of Health-MERIT award for his work in endometriosis and the American Society of Reproductive Medicine Distinguished Researcher Award.[18] [19]

Honors

Notes and References

  1. 19144942 . 10.1056/NEJMra0804690 . 360 . Endometriosis . N Engl J Med . 268–79 . Bulun . SE. 3 . 2009 .
  2. 24088094 . 10.1056/NEJMra1209993 . 369 . Uterine fibroids . N Engl J Med . 1344–55 . Bulun . SE. 14 . 2013 .
  3. https://www.ncbi.nlm.nih.gov/pubmed/?term=Dyson+MT%2C+Roqueiro+D%2C+Monsivais+D%2C+et+al.+Genome-wide+DNA+methylation+analysis+predicts+an+epigenetic+switch+for+GATA+factor+expression+in+endometriosis.+PLoS+Genet.+2014%3B10(3)%3Ae1004158. Dyson MT, Roqueiro D, Monsivais D, et al. Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis.PLoS Genet.2014;10(3):e1004158.
  4. 23303565 . 10.1210/er.2012-1043 . 34 . Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer . 3565104 . Endocr Rev . 130–62 . Kim . JJ . Kurita . T . Bulun . SE. 1 . 2013 .
  5. https://www.ncbi.nlm.nih.gov/pubmed/?term=Paracrine+activation+of+WNT%2Fbeta-catenin+pathway+in+uterine+leiomyoma+stem+cells+promotes+tumor+growth Ono M, Yin P, Navarro A, et al. Paracrine activation of WNT/beta-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.Proc Natl Acad Sci USA.2013;110:17053-8.
  6. https://www.ncbi.nlm.nih.gov/pubmed/?term=Regulation+of+aromatase+expression+in+estrogen-responsive+breast+and+uterine+disease%3A+from+bench+to+treatment Bulun SE, Lin Z, Imir G, et al. Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment.Pharmacol Rev.2005;57:359-83.
  7. https://www.ncbi.nlm.nih.gov/pubmed/?term=Estrogen+excess+associated+with+novel+gain-of-function+mutations+affecting+the+aromatase+gene Shozu M, Sebastian S, Takayama K, et al. Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene.N Engl J Med.2003;348:1855-65.
  8. https://www.ncbi.nlm.nih.gov/pubmed/?term=Regional+rearrangements+in+chromosome+15q21+cause+formation+of+cryptic+promoters+for+the+CYP19+(aromatase)+gene. Demura M, Martin RM, Shozu M, et al. Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene.Hum Mol Genet.2007;16:2529-41.
  9. 22570742 . 10.1371/journal.pone.0036935 . 7 . Role of stem cells in human uterine leiomyoma growth . 3343011 . PLOS ONE . e36935 . Ono . M . Qiang . W . Serna . VA . Yin . P . Coon . Navarro . A . Monsivais . D . Kakinuma . T . Dyson . M . Druschitz . S . Unno . K . Kurita . T . Bulun . SE. 5 . 2012 . 2012PLoSO...736935O . free .
  10. 10946900 . 10.1210/jcem.85.8.6739 . 85 . Progesterone receptor isoform A but not B is expressed in endometriosis . J Clin Endocrinol Metab . 2897–902 . Attia . GR . Zeitoun . K . Edwards . D . Johns . A . Carr . BR . Bulun . SE. 8 . 2000 . free .
  11. https://www.ncbi.nlm.nih.gov/pubmed/?term=Malignant+breast+epithelial+cells+stimulate+aromatase+expression+via+promoter+II+in+human+adipose+fibroblasts%3A+an+epithelial-stromal+interaction+in+breast+tumors+mediated+by+CCAAT%2Fenhancer+binding+protein+beta. Zhou J, Gurates B, Yang S, Sebastian S, Bulun SE. Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.Cancer Res.2001;61:2328-34.
  12. https://www.ncbi.nlm.nih.gov/pubmed/?term=Aromatase+inhibitors%3A+the+next+generation+of+therapeutics+for+endometriosis%3F Attar E, Bulun SE. Aromatase inhibitors: the next generation of therapeutics for endometriosis?Fertil Steril.2006;85:1307-18.
  13. Thieme Medical Publishers. 10.1055/s-0035-1567816. 26565385. 2015. Bulun. S. E.. Seminars in Reproductive Medicine. 33. 6. 373–4.
  14. Web site: News Center. Northwestern Medicine. 19 October 2015 .
  15. Web site: Serdar E. Bulun, M.D.. The American Society for Clinical Investigation.
  16. Web site: Member Directory. Association for American Physicians.
  17. Web site: SRI Presidents. Society for Reproductive Investigation.
  18. Web site: Endometriosis and Retinoids. Grantome.
  19. Web site: ASRM2012: Serdar Bulun honoured as distinguished researcher. endometriosis.org.
  20. Web site: Faculty Profiles. Northwestern Medicine.
  21. Web site: Bulun Appointed Gardner Clinical Professor. Northwestern University News Center.

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