| Seo | |
| Native Name Lang: | ko |
| Settlement Type: | Autonomous District |
| Translit Lang1: | Korean |
| Translit Lang1 Type1: | Hanja |
| Translit Lang1 Info2: | Seo-gu |
| Translit Lang1 Info3: | Sŏ-gu |
| Subdivision Type: | Country |
| Subdivision Name: | South Korea |
| Subdivision Type1: | Region |
| Subdivision Name1: | Honam |
| Subdivision Type2: | Provincial level |
| Subdivision Name2: | Gwangju |
| Leader Title: | Mayor |
| Leader Name: | Kim Lee-kang(김이강) |
| Subdivision Type3: | Administrative divisions |
| Area Total Km2: | 47.74 |
| Population As Of: | 2024[1] |
| Population Total: | 280,045 |
| Population Density Km2: | auto |
| Population Blank1 Title: | Dialect |
| Population Blank1: | Jeolla |
Seo District is a district of Gwangju, South Korea. Its hanja transcription means "west district", but it is in the center of the city. Its city hall and a convention center are famous landmarks in the district.
Due to the influence of Kia’s Gwangju Plant (Autoland Gwangju), this area is considered the most affluent in Gwangju. Centered around the Sangmu District, where the Gwangju Metropolitan City Hall is located, it serves as the administrative and economic core of the city. With key hubs like U-Square and the Sangmu District, it also boasts the most thriving commercial sector in Gwangju.