| Official Name: | Despotovo |
| Settlement Type: | Village (Selo) |
| Pushpin Map: | Serbia Vojvodina#Serbia#Europe |
| Pushpin Label Position: | bottom |
| Subdivision Type: | Country |
| Subdivision Name: |  Serbia |
| Subdivision Type1: | Province |
| Subdivision Type2: | Region |
| Subdivision Name2: | Bačka |
| Subdivision Type3: | District |
| Subdivision Name3: | South Bačka |
| Subdivision Type4: | Municipality |
| Subdivision Name4: | Bačka Palanka |
| Unit Pref: | Imperial |
| Population As Of: | 2002 |
| Timezone: | CET |
| Utc Offset: | +1 |
| Timezone Dst: | CEST |
| Utc Offset Dst: | +2 |
| Coordinates: | 45.45°N 32°W |
Despotovo (Serbian: Деспотово) is a village located in the Bačka Palanka municipality, in the South Bačka District of Serbia. It is situated in the autonomous province of Vojvodina. Despotovo had a total population of 2,081 inhabitants in 1991 and 2,096 in 2002. Most of the inhabitants of the village are ethnic Serbs.
During its history, Despotovo has had several names in various languages. In the Middle Ages the village was called Sentivan (Сентиван) in Serbian. In the second half of the 13th century it was called Kesi-selo (Кеси-село). By 1418, the Serbs called it Despot Sentivan (Деспот Сентиван). It was named by Despot Jovan Branković. After World War I, when village became part of the Kingdom of Yugoslavia, it was named Despot Sveti Ivan (Деспот Свети Иван, English: Despot Saint John). After World War II it changed name to Vasiljevo (Васиљево), because of Soviet soldier Vasilj who was the first soldier who entered the village after the German army abandoned it. After a few years it became known as Novo Vasiljevo (Ново Васиљево), and then, finally, Despotovo (Деспотово).
In Hungarian, the village was called Szentivankeszi in the second half of the 13th century (presumably because the family who owned it were the Sentivanji). Hungarians later accepted Serbian name Despot Sentivan and they called it like that from the 16th century to the 18th. In the 15th and 16th centuries, Hungarians called it Edzasszentivan and Kisszentivan. In 1904 Hungarians called the village Ursentivan.
Despotovo is one of the oldest villages in Bačka. When the Ottomans conquered Vojvodina many people left the village. Because of the many wars between the Habsburg monarchy and the Ottoman Empire, the village's population changed a lot from the 16th century to the 18th century, although it was mainly populated by Serbs during the Ottoman rule. After the Habsburgs defeated the Ottomans, Serbs started settling in Despotovo again. The village's first school opened in the 1770s and its church was built in 1786.
According to the 1991 census, Despotovo had a total population of 2,081 inhabitants, comprising:
In 2002, the population of the village numbered 2,096 people, including: