Senecionine N-oxygenase explained

Senecionine N-oxygenase
Ec Number:	1.14.13.101
Cas Number:	220581-68-0

In enzymology, a senecionine N-oxygenase is an enzyme that catalyzes the chemical reaction

senecionine + NADPH + H⁺ + O₂

\rightleftharpoons senecionine N-oxide + NADP⁺ + H₂O

The 4 substrates of this enzyme are senecionine, NADPH, H⁺, and O₂, whereas its 3 products are senecionine N-oxide, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O₂ as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O₂ with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is senecionine,NADPH:oxygen oxidoreductase (N-oxide-forming). Other names in common use include senecionine monooxygenase (N-oxide-forming) and SNO.

References

• Lindigkeit R, Biller A, Buch M, Schiebel HM, Boppre M, Hartmann T . 1997 . The two facies of pyrrolizidine alkaloids: the role of the tertiary amine and its N-oxide in chemical defense of insects with acquired plant alkaloids . Eur. J. Biochem. . 245 . 626 - 36 . 9182998 . 10.1111/j.1432-1033.1997.00626.x . 3 .
• Naumann C, Hartmann T, Ober D . 2002 . Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae . Proc. Natl. Acad. Sci. U.S.A. . 99 . 6085 - 90 . 11972041 . 10.1073/pnas.082674499 . 9 . 122906 . 2002PNAS...99.6085N . free .