| Seneca Vocational High School | |
| Streetaddress: | 666 East Delevan Avenue |
| City: | Buffalo |
| State: | New York |
| Zipcode: | 14215 |
| Country: | United States |
| Coordinates: | 42.9226°N -78.8324°W |
| Schoolnumber: | 306 |
| Schoolboard: | Buffalo Public Schools |
| Type: | Public, Vocational |
| Grades: | 9-12 |
| Team Name: | Indians |
| Colors: | Green and White |
| Opened: | 1907 |
| Closed: | 2008 |
Seneca Vocational High School, also known as Seneca Comprehensive High School and Seneca High School, is a former vocational high school located in Buffalo, New York. It was one of the first vocational schools built in Western New York. The building, located at 666 East Delavan Avenue in Buffalo, currently serves home to The Math, Science, Technology Preparatory School.
Seneca was the oldest vocational high school in Buffalo, and was constructed three months after the first vocational school in the state of New York was completed. The building was constructed in 1925 and received an addition in 1955. Seneca High School stopped admitting new students in 2006, although it remained open so that the remaining classes of 2007 and 2008 were allowed to graduate. In the fall of 2006, the school reopened as the Math Science and Tech Prep at Seneca. From 2010 to 2012, the Seneca building was renovated by LPCiminelli. During that time, MST Prep students were educated at Black Rock Academy until Seneca was ready to be re-opened.
Previous assignment and reason for departure denoted in parentheses